Expert Interview 2: Frequently Asked Questions (FAQs) for Muscle-Invasive Bladder Cancer (MIBC)
Release date: 04-12-2023
Expiration date: 04-12-2024
Muscle-Invasive Bladder Cancer (MIBC) is defined as the tumor has spread through the bladder lining and into the bladder muscle. Optimal treatment strategies for MIBC requires the involvement of a specialist multidisciplinary team (MDT), with collaboration between surgeons, medical oncologists, radiation oncologists, pathologists and other specialists.
Bladder preservation is an alternative to cystectomy for patients deemed unfit for surgery. The MDT board should develop a treatment strategy tailored to meet the needs of patients seeking bladder preservation. The management of locally advanced operable bladder cancer and the role of pre and postoperative systemic treatments have become increasingly intricate. Neoadjuvant cisplatin-based chemotherapy has been the standard of care for some years. Adjuvant immunotherapy has now emerged as a new standard of care for postoperative patients with high risks. Nonetheless, there remain gaps that need to be addressed for practicing oncologists to gain an in-depth understanding of individualized treatment strategies for MIBC.
Let's watch the recorded video on 'Frequently Asked Questions (FAQs) for MIBC' to gain comprehensive insights from leading experts – Dr. Francisco X. Real from National Cancer Research Center of Spain, Dr. Félix Guerrero Ramos from Hospital Universitario 12 de Octubre in Madrid, Dr. Natalia Carballo and Dr. Enrique Grande from MD Anderson Cancer Center Madrid.
This program is available with subtitles in the following languages:
参与专家
Francisco X. Real 教授
国家癌症研究中心
西班牙马德里
Francisco X. Real（Paco），MD，PhD自2004年起任西班牙巴塞罗那庞贝大学法布拉分校细胞生物学教授，2007年起也在西班牙马德里西班牙国家癌症研究中心（CNIO）工作。他于1980年在巴塞罗那大学获得MD学位，于1986年获得PhD学位。1986年至1988年在纽约纪念医院接受肿瘤内科培训，并担任内科医师。他在纪念斯隆-凯特琳癌症中心（MSKCC）的Lloyd J. Old实验室开展了博士和博士后工作。他关注于开发治疗黑色素瘤和上皮癌的免疫学策略。1988年，他加入了巴塞罗那市立医学研究所，在那里他专注于上皮癌的细胞和分子生物学。他还参与了庞培法布拉大学生物医学科学研究所的建立。
在CNIO，Real教授的研究组在胰腺癌和胰腺炎的分子机制以及膀胱癌和胰腺癌的分子病理学和流行病学领域做出了重大贡献。他的工作结合了患者样本、培养细胞和转基因小鼠的使用，并使用所有研究材料去探索出相近的相关性。该研究组工作的一个重要目的是使实验室产生的基础知识去提高对疾病的认识，并制定预防、早期诊断和治疗胰腺癌和膀胱癌的改进策略。
Real教授已发表原创性论文300余篇，其论文发表在Nature、Nature Genetics、Nature Cell Biology、Nature Communications、Nature Reviews Cancer、Gut、Gastroenterology、PNAS、JNCI、J Clin Invest、N Engl J Med、Lancet等杂志。他的论文被引用超过29000次（谷歌学术搜索），他的H指数为96。他是多个机构科学咨询委员会的成员，包括英国癌症研究研发委员会（伦敦）、Cordeliers研究中心（巴黎）、CARPEM（巴黎）、英国胰腺癌研究中心（伦敦）和国家科学研究基金会（布鲁塞尔）。他是Gut和Bladder Cancer的副主编。2015年，曾任欧洲胰腺俱乐部主席。
Enrique Grande 教授 | 主席
MD Anderson肿瘤中心马德里分院
西班牙马德里
Enrique Grande，MD，MSc，PhD 是MD Anderson肿瘤中心马德里分院肿瘤学项目的现任医学总监，Grande医生关注泌尿生殖肿瘤领域的研究，积极参与并投身于转化研究和药物早期研发部门的发展与合作。Grande医生获得PhD学位的研究方向为酪氨酸激酶抑制剂肝代谢的药代动力学和药效动力学，他曾在西班牙国家癌症研究中心（CNIO）获得分子生物学的硕士学位。他曾在同行评议的学术期刊上发表了超过200篇论文，同时也是西班牙孤儿药和罕见肿瘤研究组（GETHI）的创始人。Grande医生是很多国际期刊的编辑，也是肿瘤领域众多书籍著作的编辑。他曾参加过泌尿生殖肿瘤及神经内分泌肿瘤领域很多最新的临床研究，也帮助众多新药获得上市批准，为临床提供了更多治疗选择。
Natalia Carballo 教授
MD Anderson肿瘤中心马德里分院
西班牙马德里
Natalia Carballo是西班牙马德里MD Anderson肿瘤中心的现任放射肿瘤科主任。她还是美国德克萨斯州休斯顿MD Anderson肿瘤中心和马德里弗朗西斯科维多利亚大学的放射肿瘤学副教授。
Carballo专注于胸部和胃肠道肿瘤学，对特殊技术尤其感兴趣，包括放射外科、超低分割和深吸气屏气（DIBH）技术。她还是国家癌症研究所（NCI）国际项目“癌症登月计划肺癌筛查研究”的首席研究员，并且是欧洲放射肿瘤学会（ESTRO）2021年马德里大会的当地组织者。Carballo还参与了很多西班牙的学术委员会，并且是放射治疗领域的意见领袖。
Félix Guerrero 教授
Doce de Octubre医院
西班牙马德里
Félix Guerrero-Ramos是西班牙马德里12 de Octubre大学医院肿瘤泌尿科的共同负责人，并作为泌尿科医生为患者提供外科手术治疗。他还是12 de Octubre大学医院的住院项目主任，同时也是马德里康普顿斯大学（医学院）最后一年学生的学术导师。此外，Guerrero-Ramos是CEU San Pablo大学的医学副教授。他还同时在马德里HM医院和ROC诊所兼任肿瘤泌尿科主任。
Guerrero-Ramos于2008年在马德里自治大学获得医学博士学位，随后在12 de Octubre大学医院接受泌尿科医生培训。在住院实习期间，他还在英国伦敦大学学院医院完成了临床见习。2014年6月他在比利时布鲁塞尔的欧洲泌尿外科委员会获得奖学金，并于2015年12月以优异的成绩获得马德里康普顿斯大学的博士学位。他的博士论文题目是“在常温保存下非对照的DCD肾脏捐献项目中手术并发症的比较分析”。
Guerrero-Ramos的研究主要集中在泌尿肿瘤学（尤其是膀胱癌和肾癌）。他是多个尿路上皮癌和肾癌I/II/III期研究的首席研究员。他曾受邀在国内和国际会议上发表演讲，还组织和主持过多个课程和会议，主要关注尿路上皮癌和肾癌。他在同行评议期刊上发表超过45篇科学文章，在多个全球大会上发表了100多篇通讯，以及12本著作章节。
This activity is design designed for medical oncologists and urologists involved or interested in the management of urothelial cancer.
The aim of this educational activity is for participants to:
- Become familiar with the indications and limitations of local treatments for MIBC
- Establish confidence in the selection of optimal strategies for bladder preservation and neoadjuvant/adjuvant treatment through MDT approach
This educational activity is provided by ACE Oncology.
This educational activity is supported by an independent grant from the Healthcare business of Merck KGaA, Darmstadt, Germany.
This activity provides content that is evidence-based, balanced, and free of commercial bias, with a primary objective to improve competence and performance of learners in order to improve patient care.
The faculty reported the following financial relationships or relationships to products or devices they or their spouses/life partners have with commercial interest related to the content of this activity:
Enrique Grande has received honoraria for speaker engagements, advisory roles or funding for continuing medical education from Advanced Accelerator Applications, AMGEN, Angelini, Astellas, Astra Zeneca, Bayer, Blueprint, Bristol Myers Squibb, Caris Life Sciences, Celgene, Clovis-Oncology, Dr. Reddy’s, Eisai, Esteve, Eusa Pharma, Genetracer, GSK, Guardant Health, HRAPharma, IPSEN, ITM-Radiopharma, Janssen, Lexicon, Lilly, Merck KGaA, MSD, Nanostring Technologies, Natera, Novartis, ONCODNA (Biosequence), Palex, Pharmamar, Pierre Fabre, Pfizer, Raffo, Roche, Sanofi-Genzyme, Servier, Taiho, Tecnofarma, Thermo Fisher Scientific and Zodiac. He has also received grants for clinical research from Astellas, Astra Zeneca, IPSEN, Lexicon, Merck KGaA, MTEM/Threshold/Tersera, Nanostring Technologies, Pfizer and Roche. He has agreed to disclose any unlabeled/unapproved uses of drugs or products referenced in his presentation.
Félix Guerrero has served as an advisor or consultant for Pfizer, BMS, AstraZeneca, Janssen and Combat Medical. He has also served as a speaker or a member of a speakers bureau for Astellas Oncology, Janssen, Pfizer, AstraZeneca, Combat Medical and Nucleix. He has agreed to disclose any unlabeled/unapproved uses of drugs or products referenced in his presentation.
Francisco X. Real has received grants for research from VCN Biosciences and Janssen. He has agreed to disclose any unlabeled/unapproved uses of drugs or products referenced in his presentation.
Natalia Carballo has no financial relationships to disclose. She has agreed to disclose any unlabeled/unapproved uses of drugs or products referenced in her presentation.
The employees of ACE Oncology have disclosed no relevant financial relationships.
ACE Oncology requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest (COI) they may have as related to the content of this activity. All identified COIs are thoroughly vetted and resolved according to ACE Oncology’s policy. ACE Oncology is committed to providing its learners with high-quality activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial entity.