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\u5e7f\u6cdb\u671f\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u6cbb\u7597<\/h3>\n\n\n\n
<\/div>\n\n\n\n

\u60a3\u8005\u75c5\u4f8b\uff1a<\/em><\/strong><\/p>\n\n\n\n

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\u6570\u5341\u5e74\u6765\uff0c\u4ee5\u94c2\u7c7b\u4e3a\u57fa\u7840\u7684\u5316\u7597\u662f\u4e00\u7ebf\u6cbb\u7597\u7684\u91d1\u6807\u51c6\u3002\u5728\u6b27\u6d32\u548c\u7f8e\u56fd\uff0c\u94c2\u7c7b\u5316\u7597\u5305\u62ec4~6\u4e2a\u5468\u671f\u7684\u987a\u94c2\u6216\u5361\u94c2+\u4f9d\u6258\u6cca\u82f7\uff08EP\uff092,3,4<\/sup>\uff0c\u5728\u65e5\u672c\u5305\u62ec\u94c2\u7c7b+\u4f0a\u7acb\u66ff\u5eb74,5<\/sup>\u3002\u603b\u4f53\u800c\u8a00\uff0c\u4e0e\u987a\u94c2\u76f8\u6bd4\uff0c\u5361\u94c2\u5177\u6709\u76f8\u4f3c\u7684\u7597\u6548\u548c\u8f83\u597d\u7684\u6bd2\u6027\uff0c\u5e76\u4e14\u80be\u6bd2\u6027\u3001\u8033\u6bd2\u6027\u548c\u795e\u7ecf\u75c5\u53d8\u8f83\u5c11\uff0c\u4f46\u8840\u6db2\u5b66\u6bd2\u6027\u8f83\u9ad83<\/sup>\u3002<\/p>\n\n\n\n

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\u60a3\u8005\u75c5\u7a0b\uff1a<\/p>\n\n\n\n

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\u590d\u53d1ES SCLC\u7684\u6cbb\u7597\u65b9\u6848\u662f\u4ec0\u4e48\uff1f<\/p>\n\n\n\n

\u5927\u591a\u6570ES SCLC\u60a3\u8005\u5728\u4e00\u7ebf\u6cbb\u7597\u540e\u6216\u6cbb\u7597\u671f\u95f4\u590d\u53d1\u6216\u8fdb\u5c55\u3002\u867d\u7136\u4e8c\u7ebf\u6cbb\u7597\u53ef\u80fd\u572810-30%\u7684\u60a3\u8005\u4e2d\u4ea7\u751f\u5e94\u7b54\uff0c\u4f46\u8fd9\u4e9b\u5e94\u7b54\u901a\u5e38\u662f\u77ed\u6682\u7684\uff0c\u4e2d\u4f4d\u751f\u5b58\u671f\u7ea6\u4e3a6-10\u4e2a\u670817<\/sup>\u3002\u5bf9\u6cbb\u7597\u5e94\u7b54\u7684\u53ef\u80fd\u6027\u9ad8\u5ea6\u4f9d\u8d56\u4e8e\u4ece\u521d\u59cb\u5316\u7597\u5230\u590d\u53d1\u7684\u65f6\u95f4\u548c\u521d\u59cb\u6cbb\u7597\u53cd\u5e94\u7684\u6301\u7eed\u65f6\u95f4\u3002\u8fbe\u5230\u5b8c\u5168\uff08CR\uff09\u6216\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\u7684\u60a3\u8005\uff0c\u5728\u6700\u540e\u4e00\u6b21\u4e00\u7ebf\u5316\u7597\u540e\u8d85\u8fc790\u5929\u4ee5\u4e0a\u624d\u590d\u53d1\uff0c\u88ab\u79f0\u4e3a\u201c\u654f\u611f\u201d\uff1b\u800c\u5728\u6700\u540e\u4e00\u6b21\u4e00\u7ebf\u5316\u7597\u540e<90\u5929\u590d\u53d1\uff0c\u6216\u5bf9\u4e00\u7ebf\u5316\u7597\u65e0\u53cd\u5e94\u88ab\u79f0\u4e3a\u201c\u8010\u836f\u201d\u6216\u201c\u96be\u6cbb\u6027\u201d17<\/sup>\u3002<\/p>\n\n\n\n

\u5f53\u60a3\u8005\u5728\u8fdb\u5c55\u540e\u82e5PS\u826f\u597d\uff0c\u5982\u679c\u6709\u5408\u9002\u7684\u673a\u4f1a\uff0c\u6700\u597d\u53c2\u52a0\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n\n\n\n

\u6807\u51c6\u7684\u4e8c\u7ebf\u6cbb\u7597\u9009\u62e9\u5305\u62ec\u62d3\u6251\u66ff\u5eb7\uff08\u53e3\u670d\u6216\u9759\u8109\u6ce8\u5c04\uff09\u548c\u9c81\u6bd4\u5361\u4e01\uff0c\u5bf9\u4e8e\u836f\u7269\u654f\u611f\u6027\u590d\u53d1\u7684\u60a3\u8005\uff0c\u5982\u679c\u4ed6\u4eec\u7684\u4f53\u529b\u72b6\u6001\u5141\u8bb8\uff0c\u53ef\u4ee5\u91cd\u65b0\u4f7f\u7528\u4e00\u7ebf\u542b\u94c2\u65b9\u6848\uff08\u901a\u5e38\u662fEP\uff0918<\/sup>\u3002\u9c81\u6bd4\u5361\u4e01\u662f\u4e00\u79cd\u65b0\u578b\u70f7\u57fa\u5316\u5242\uff08\u7c7b\u4f3c\u4e8e\u66f2\u8d1d\u66ff\u5b9a\uff09\uff0c\u5b83\u4e0eDNA\u7684\u5c0f\u6c9f\u69fd\u7ed3\u5408\u5e76\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u8f6c\u5f55\u3002\u5728\u5355\u81c2II\u671f\u7814\u7a76\u4e2d\uff0c\u57fa\u4e8e35%\u7684\u53cd\u5e94\u7387\u3001\u7ea65\u4e2a\u6708\u7684\u53cd\u5e94\u6301\u7eed\u65f6\u95f4\u548c9\u4e2a\u6708\u7684OS\uff0c\u8be5\u836f\u7269\u83b7\u5f97\u4e86\u4e8c\u7ebf\u6cbb\u7597\u7684\u52a0\u901f\u6279\u51c619<\/sup>\u3002\u5b83\u7684\u8840\u6db2\u5b66\u6bd2\u6027\u6bd4\u62d3\u6251\u66ff\u5eb7\u5c0f\uff0c\u4f46\u8f6c\u6c28\u9176\u5347\u9ad8\u7684\u53d1\u751f\u7387\u66f4\u9ad8\u3002\u9c81\u6bd4\u5361\u4e01+\u963f\u9709\u7d20\u4e0e\u62d3\u6251\u66ff\u5eb7\u6216CAV\uff08\u73af\u78f7\u9170\u80fa\u3001\u963f\u9709\u7d20\u3001\u957f\u6625\u65b0\u78b1\uff09\u7684III\u671fATLANTIS\u7814\u7a76\u672a\u80fd\u63d0\u9ad8\u751f\u5b58\u7387\u3002\u7136\u800c\uff0c\u8054\u5408\u4f7f\u7528\u9c81\u6bd4\u5361\u4e01\u7684\u5242\u91cf\u660e\u663e\u4f4e\u4e8e\u5355\u836f\u6cbb\u759720<\/sup>\u3002<\/p>\n\n\n\n

\u5728\u4e8c\u7ebf\u6cbb\u7597\u8fdb\u5c55\u540e\uff0c\u4e5f\u5e94\u8003\u8651\u7eb3\u5165\u4e34\u5e8a\u8bd5\u9a8c\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u5982\u679c\u60a3\u8005\u7684\u60c5\u51b5\u5141\u8bb8\uff0c\u4e09\u7ebf\u6cbb\u7597\u53ef\u5305\u62ec\u4ee5\u524d\u672a\u7ed9\u4e88\u7684\u836f\u7269\uff08\u62d3\u6251\u66ff\u5eb7\u6216\u9c81\u6bd4\u5361\u4e01\uff09\uff0c\u6216\u5176\u4ed6\u6d3b\u6027\u9002\u4e2d\u7684\u836f\u7269\uff08\u5982\u7d2b\u6749\u70f7\u7c7b\u3001\u4f0a\u7acb\u66ff\u5eb7\u3001\u66ff\u83ab\u5511\u80fa\u3001\u53e3\u670d\u4f9d\u6258\u6cca\u82f7\u6216\u5409\u897f\u4ed6\u6ee8\uff0917<\/sup>\u3002\u5728\u4e00\u7ebf\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u6cbb\u7597\u8fdb\u5c55\u540e\uff0c\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u5982\u5e15\u535a\u5229\u73e0\u5355\u6297\u548c\u7eb3\u6b66\u5229\u5c24\u5355\u6297\u80fd\u5426\u5728\u540e\u7ebf\u6cbb\u7597\u4e2d\u4f7f\u7528\uff0c\u76ee\u524d\u5c1a\u4e0d\u6e05\u695a\u3002<\/p>\n\n\n\n

PS 2\u60a3\u8005\u80fd\u5426\u63a5\u53d7\u4e8c\u7ebf\u6cbb\u7597\uff1f<\/p>\n\n\n\n

ECOG PS 2\u60a3\u8005\u88ab\u7eb3\u5165\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f46\u53ef\u8003\u8651\u51cf\u5c11\u521d\u59cb\u5242\u91cf\u6216\u6dfb\u52a0\u751f\u957f\u56e0\u5b50\u652f\u6301\u3002\u6b64\u5916\uff0cFDA\u6700\u8fd1\u6279\u51c6\u4e86\u66f2\u62c9\u897f\u5229\uff0c\u4e00\u79cd\u5468\u671f\u86cb\u767d\u4f9d\u8d56\u6027\u6fc0\u9176\uff08CDK\uff094\/6\u7684\u6291\u5236\u5242\uff0c\u7528\u4e8e\u5728\u60a3\u8005\u4f7f\u7528\u542bEP\u65b9\u6848\u6216\u542b\u62d3\u6251\u66ff\u5eb7\u65b9\u6848\u6cbb\u7597\u524d\uff0c\u9884\u9632\u6027\u964d\u4f4e\u5316\u7597\u5bfc\u81f4\u7684\u9aa8\u9ad3\u6291\u5236\u7684\u53d1\u751f\u7387\u3002\u66f2\u62c9\u897f\u5229\u8bf1\u5bfc\u9aa8\u9ad3\u4e2d\u589e\u6b96\u7684\u9020\u8840\u5e72\u7ec6\u80de\u548c\u7956\u7ec6\u80de\u77ed\u6682\u7684\u3001\u53ef\u9006\u7684G1\u7ec6\u80de\u5468\u671f\u963b\u6ede\uff0c\u4ece\u800c\u4fdd\u62a4\u5b83\u4eec\u514d\u53d7\u5316\u7597\u7684\u635f\u5bb3\uff08\u9aa8\u9ad3\u4fdd\u62a4\uff0919<\/sup>\u3002<\/p>\n\n\n\n

\u4e0eNSCLC\u76f8\u6bd4\uff0c\u5206\u5b50\u68c0\u6d4b\u548c\u9776\u5411\u6cbb\u7597\u662f\u6807\u51c6\u6cbb\u7597\uff0cSCLC\u6ca1\u6709\u9776\u5411\u6cbb\u7597\uff0c\u5bf9\u4e2a\u6027\u5316\u751f\u7269\u6807\u5fd7\u7269\u9a71\u52a8\u6cbb\u7597\u7684\u9700\u6c42\u5f88\u9ad8\u3002<\/p>\n\n\n\n

SCLC\u5206\u578b\u6709\u671b\u6210\u4e3a\u672a\u6765\u751f\u7269\u6807\u5fd7\u7269\u9a71\u52a8\u7684\u4e2a\u6027\u5316\u6cbb\u7597<\/p>\n\n\n\n

\u57fa\u56e0\u7ec4\u5b66\u7684\u8fdb\u6b65\u4ee5\u53ca\u591a\u79cd\u5c0f\u9f20\u548c\u60a3\u8005\u884d\u751f\u6a21\u578b\u7684\u5f00\u53d1\uff0c\u4f7f\u4eba\u4eec\u66f4\u597d\u5730\u4e86\u89e3SCLC\u7684\u751f\u7269\u591a\u6837\u6027\u3002SCLC\u7684\u57fa\u56e0\u7ec4\u5206\u6790\u7814\u7a76\u663e\u793a\uff0cSCLC\u5b58\u5728\u5e7f\u6cdb\u7684\u67d3\u8272\u4f53\u91cd\u6392\u548c\u8f83\u9ad8\u7684\u7a81\u53d8\u8d1f\u62c5\uff0c\u5e76\u8bc1\u5b9e\u51e0\u4e4e\u6240\u6709SCLC\u90fd\u5b58\u5728\u4e24\u79cd\u5173\u952e\u6291\u764c\u57fa\u56e0TP53\u548cRB1\u7684\u529f\u80fd\u7f3a\u5931\u3002MYC\u5bb6\u65cf\u57fa\u56e0\u7684\u6269\u589e\u6216\u8fc7\u8868\u8fbe\u4e5f\u5f88\u5e38\u89c1\uff0cNOTCH\u5bb6\u65cf\u57fa\u56e0\u7684\u5931\u6d3b\u7a81\u53d8\u3001PTEN\u7f3a\u5931\u3001PI3K\u7a81\u53d8\u548cFGFR1\u6269\u589e\uff0c\u4ee5\u53ca\u5f71\u54cd\u8868\u89c2\u9057\u4f20\u8c03\u63a7\u56e0\u5b50\u7684\u7a81\u53d8\u4e5f\u5f88\u5e38\u89c120,21<\/sup>\u3002<\/p>\n\n\n\n

\u6700\u8fd1\u7684\u7814\u7a761,21,22<\/sup>\u8868\u660eSCLC\u8868\u73b0\u51fa\u80bf\u7624\u5185\u548c\u80bf\u7624\u95f4\u5f02\u8d28\u6027\uff0c\u5e76\u53ef\u5206\u4e3a\u56db\u4e2a\u751f\u7269\u5b66\u4e0a\u4e0d\u540c\u7684\u4e9a\u578b\uff1a\u795e\u7ecf\u5185\u5206\u6cccSCLC-A\u548cSCLC-N\u4ee5\u53ca\u975e\u5185\u5206\u6cccSCLC-P\u548cSCLC-I\u3002\u8fd9\u4e9b\u4e9a\u578b\u662f\u6839\u636e\u4e3b\u8f6c\u5f55\u56e0\u5b50\uff08ASCL1\u3001NEUROD1\u548cPOU2F3\uff09\u7684\u5dee\u5f02\u8868\u8fbe\u6765\u5b9a\u4e49\u7684\uff0c\u5bf9\u4e8eSCLC-I\uff0c\u662f\u6839\u636e\u6240\u6709\u4e09\u79cd\u8f6c\u5f55\u56e0\u5b50\u7684\u4f4e\u8868\u8fbe\u6216\u7f3a\u5931\u4ee5\u53ca\u708e\u75c7\u57fa\u56e0\u6807\u8bb0\u6765\u5b9a\u4e49\u768421,22<\/sup>\u3002\u6bcf\u79cd\u4e9a\u578b\u90fd\u88ab\u53d1\u73b0\u4e0e\u4e0d\u540c\u7684\u6cbb\u7597\u8106\u5f31\u6027\u76f8\u5173\u3002\u4f8b\u5982\uff0c\u5177\u6709\u514d\u75ab\u708e\u75c7\u8868\u578b\u7684SCLC-I\uff0c\u53ef\u80fd\u4ece\u5316\u7597\u7684\u514d\u75ab\u6cbb\u7597\u4e2d\u5f97\u5230\u6700\u5927\u7684\u83b7\u76ca\u3002\u8fd9\u5728\u9488\u5bf9IMpower133\u751f\u5b58\u6570\u636e\u7684\u4e9a\u578b\u7279\u5f02\u6027\u56de\u987e\u6027\u5206\u6790\u4e2d\u5f97\u5230\u9a8c\u8bc1\uff0c\u5176\u4e2dSCLC-I\u4e9a\u578b\u76f8\u5bf9\u4e8e\u5316\u7597\u8054\u5408\u514d\u75ab\u6cbb\u7597\u7684\u5176\u4ed6\u4e9a\u578b\u6709\u663e\u8457\u7684OS\u83b7\u76ca\uff0c\u4f46\u5b89\u6170\u5242\u8054\u5408\u514d\u75ab\u6cbb\u7597\u5219\u6ca1\u6709\u6b64\u73b0\u8c6122<\/sup>\u3002\u6765\u81eaCASPIAN\u7814\u7a76\u7684\u5206\u578b\u5206\u6790\u652f\u6301\u8fd9\u4e9b\u53d1\u73b023<\/sup>\u3002\u5176\u4ed6\u4e9a\u578b\u5404\u6709\u4e0d\u540c\u7684\u8106\u5f31\u6027\uff0c\u5305\u62ecPARP\u6291\u5236\u5242\uff08SCLC-A\uff09\uff0c\u6781\u5149\u6fc0\u9176\u6291\u5236\u5242\uff08SCLC-N\uff09\uff0c\u6216BCL-2\u6291\u5236\u5242\uff08SCLC-A\uff09\u3002\u6b64\u5916\uff0c\u6bcf\u79cd\u5206\u578b\u90fd\u88ab\u53d1\u73b0\u4e0e\u72ec\u7279\u7684\u86cb\u767d\u8d28\u8868\u8fbe\u6a21\u5f0f\u76f8\u5173\uff0c\u8fd9\u53ef\u80fd\u662f\u6f5c\u5728\u7684\u836f\u7269\u9776\u70b9\u548c\u9884\u6d4b\u6027\u751f\u7269\u6807\u5fd7\u72691<\/sup>\u3002\u4f8b\u5982\uff0cDelta\u6837\u914d\u4f533\uff08DLL3\uff09\u5728SCLC-A\u4e9a\u578b\u4e2d\u9ad8\u8868\u8fbe\uff0c\u53ef\u80fd\u9884\u6d4bDDL3\u9776\u5411\u6cbb\u7597\uff0c\u5982\u53cc\u7279\u5f02\u6027T\u8854\u63a5\u6297\u4f53\u3002Schlafen-1\u86cb\u767d\uff08SLFN1\uff09\u4e5f\u88ab\u53d1\u73b0\u5728SCLC-A\u4e9a\u578b\u4e2d\u8868\u8fbe\u5dee\u5f02\u6700\u5927\uff0c\u8fd9\u53ef\u80fd\u9884\u793a\u94c2\u7c7b\u4e3a\u57fa\u7840\u7684\u5316\u7597\u548cPARP\u6291\u5236\u5242\u7684\u6f5c\u5728\u83b7\u76ca\u3002SCLC-N\u4e9a\u578b\u9ad8\u5ea6\u8868\u8fbe\u751f\u957f\u6291\u7d20\u53d7\u4f532\uff08SSTR2\uff09\uff0c\u8fd9\u662f\u751f\u957f\u6291\u7d20\u7c7b\u4f3c\u7269\u7684\u5df2\u77e5\u9776\u70b9\uff0cSCLC-I\u5177\u6709\u5e03\u9c81\u987f\u916a\u6c28\u9178\u6fc0\u9176\uff08BTK\uff09\u7684\u9ad8\u8868\u8fbe\uff0c\u8fd9\u662fBTK\u6291\u5236\u5242\u5982\u4f0a\u5e03\u66ff\u5c3c\u7684\u9776\u70b91,22,24<\/sup>\u3002<\/p>\n\n\n\n

\u6b64\u5916\uff0c\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u7684\u4e9a\u578b\u8f6c\u6362\uff08\u80bf\u7624\u53ef\u5851\u6027\uff09\u4f3c\u4e4e\u662f\u83b7\u5f97\u6027\u8010\u836f\u7684\u91cd\u8981\u673a\u5236\uff0c\u5e76\u53ef\u80fd\u5177\u6709\u6cbb\u7597\u610f\u4e4925<\/sup>\u3002\u7136\u800c\uff0c\u786e\u5b9a\u8010\u836f\u9700\u8981\u5728\u80bf\u7624\u8fdb\u5c55\u540e\u8fdb\u884c\u518d\u6b21\u6d3b\u68c0\uff0c\u8fd9\u53ef\u80fd\u5177\u6709\u6311\u6218\u6027\uff0c\u4f46\u6db2\u4f53\u6d3b\u68c0\uff08cfDNA\/ctDNA\uff09\u662f\u53ef\u884c\u7684\uff0c\u8fd9\u5c06\u4f7f\u76d1\u6d4b\u75be\u75c5\u7684\u52a8\u6001\u53d8\u5316\u6210\u4e3a\u53ef\u80fd26<\/sup>\u3002<\/p>\n\n\n\n

\u603b\u4e4b\uff0c\u5bf9\u590d\u6742\u751f\u7269\u5b66\u7684\u66f4\u597d\u7406\u89e3\u548c\u8bc6\u522b\u5177\u6709\u7279\u5b9a\u6cbb\u7597\u8106\u5f31\u6027\u7684\u5206\u5b50\u4e9a\u578b\uff0c\u4e3aSCLC\u7684\u4e2a\u6027\u5316\u6cbb\u7597\u7b56\u7565\u548c\u6539\u5584\u9884\u540e\u6253\u5f00\u4e86\u65b0\u7684\u89c6\u91ce\u548c\u5e0c\u671b\u3002<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>\n\n\n\n

  1. Rudin C, et al. Nat Rev Dis Primers. <\/em>2021;7(1):3.<\/li>
  2. Pujol JL, et al. Br J Cancer<\/em>. 2000;83:8-15.<\/li>
  3. Rossi A, et al. J Clin Oncol<\/em>. 2012;30(14):1692-1698.<\/li>
  4. Lara PN, et al. J Clin Oncol<\/em>. 2009;27:2530-2535.<\/li>
  5. Noda K, et al. N Engl J Med. <\/em>2002;346:85-91.<\/li>
  6. Liu SV, et al. J Clin Oncol. <\/em>2021;39(6):619-630.<\/li>
  7. Paz-Ares L, et al. Lancet. <\/em>2019;394(10212):1929-1939.<\/li>
  8. Paz-Ares L, et al. ESMO Open<\/em>. 2022;7(2):100408.<\/li>
  9. Rudin CM, et al. J Clin Oncol. <\/em>2020;38(21):2369-2379.<\/li>
  10. Rudin C, et al. WCLC<\/em> 2022; OA12.06.<\/li>
  11. Wang J, et al. Lancet Oncol. <\/em>2022;23(6):739-747.<\/li>
  12. Cheng Y, et al. ASCO <\/em>2022; Abstract 8505.<\/li>
  13. Slotman BJ, et al. Lancet <\/em>2015;385(9962):36-42.<\/li>
  14. Slotman BJ, et al. Transl Lung Cancer Res. <\/em>2015;4(3):292-294.<\/li>
  15. Slotman et al. N Engl J Med<\/em>. 2007;357:664-672.<\/li>
  16. Takahashi T, et al. Lancet Oncol. <\/em>2017;18(5):663-671.<\/li>
  17. Dingemans AC, et al. Ann Oncol<\/em>. 2021;32(7):839-853.<\/li>
  18. Baize N, et al. Lancet Oncol. <\/em>2020;21(9):1224-1233.<\/li>
  19. Weiss J, et al. Clin Lung Cancer<\/em>. 2021;22:449.<\/li>
  20. George J, et al. Nature<\/em>. 2015;524(7563):47-53.<\/li>
  21. Rudin CM, et al. Nat Rev Cancer. <\/em>2019;19:289-297.<\/li>
  22. Gay CM, et al. Cancer Cell. <\/em>2021;39(3):346-360.e7.<\/li>
  23. Xie M, et al. AACR<\/em> 2022; Abstract CT024.<\/li>
  24. Zhang B, et al. Am Soc Clin Oncol Educ Book. 2021 Mar;41:1-10.<\/li>
  25. Sutherland KD, et al. Genes Dev.<\/em> 2022;36:241-258.<\/li>
  26. Mondelo-Mac\u00eda P. Biomedicines<\/em>. 2021:9:48.<\/li><\/ol>\n\n\n\n

    <\/p>\n","protected":false},"excerpt":{"rendered":"

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