{"id":2660,"date":"2021-09-23T10:43:05","date_gmt":"2021-09-23T10:43:05","guid":{"rendered":"https:\/\/aceoncology.org\/?p=2660"},"modified":"2021-10-25T07:27:34","modified_gmt":"2021-10-25T07:27:34","slug":"genomic-heterogeneity-in-circulating-tumor-dna-during-therapy-and-mcrc-prognosis","status":"publish","type":"post","link":"https:\/\/aceoncology.org\/zh-hans\/genomic-heterogeneity-in-circulating-tumor-dna-during-therapy-and-mcrc-prognosis\/","title":{"rendered":"\u6cbb\u7597\u671f\u95f4ctDNA\u57fa\u56e0\u7ec4\u5f02\u8d28\u6027\u6216\u5f71\u54cdmCRC\u9884\u540e"},"content":{"rendered":"\n<p>\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684 RAS\u3001 BRAF<sup>V600E<\/sup>\u548cMMR\/MSI\u7b49\u5206\u5b50\u68c0\u6d4b\u662f\u5e2e\u52a9\u6539\u5584\u60a3\u8005\u7ed3\u5c40\u7684\u4e2a\u4f53\u5316\u6cbb\u7597\u9009\u62e9\u7684\u5173\u952e\uff1b\u4e8c\u4ee3\u6d4b\u5e8f\uff08NGS\uff09\u7b49\u6280\u672f\u7684\u53d1\u5c55\u8868\u660eCRC\u662f\u4e00\u79cd\u9ad8\u5ea6\u5f02\u8d28\u6027\u7684\u75be\u75c5\u3002\u6b64\u5916\uff0c\u5df2\u8bc1\u5b9e\u80bf\u7624\u5185\u6f14\u53d8\u7684\u5206\u5b50\u5f02\u8d28\u6027\uff08\u65f6\u95f4\u5f02\u8d28\u6027\uff09\u53ef\u5f15\u8d77\u6cbb\u7597\u8010\u836f\u3002\u5c3d\u7ba1\u7ec4\u7ec7\u6d3b\u68c0\u662f\u5206\u5b50\u68c0\u6d4b\u7684\u6807\u51c6\u6cbb\u7597\uff0c\u4f46\u8840\u6d46\u6837\u672cctDNA\u6d4b\u5e8f\uff08\u6db2\u4f53\u6d3b\u68c0\uff09\u662f\u4e00\u79cd\u975e\u4fb5\u5165\u6027\u66ff\u4ee3\u65b9\u6cd5\uff0c\u5176\u5728CRC\u7ba1\u7406\u8fc7\u7a0b\u4e2d\u7684\u5e94\u7528\u8d8a\u6765\u8d8a\u591a\u3002\u4f17\u6240\u5468\u77e5\uff0cctDNA\u53ef\u4ee5\u8ffd\u8e2amCRC\u4e2d\u7684RAS\u514b\u9686\uff0c\u5e76\u53ef\u80fd\u901a\u8fc7\u6297EGFR\u518d\u6311\u6218\u6307\u5bfc\u6cbb\u7597\u9009\u62e9\u3002\u7136\u800c\uff0cctDNA\u5982\u4f55\u5728\u5168\u8eab\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u6355\u83b7\u4f53\u7ec6\u80de\u7a81\u53d8\u7684\u8fdb\u5316\uff0c\u4ee5\u53ca\u8fd9\u79cd\u57fa\u56e0\u7ec4\u5f02\u8d28\u6027\u5bf9\u60a3\u8005\u9884\u540e\u7684\u5f71\u54cd\uff0c\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u672a\u77e5\u7684\u3002<\/p>\n\n\n\n<p>\u6765\u81ea\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u7684\u7814\u7a76\u56e2\u961f\u5c1d\u8bd5\u5728171\u4f8b\u63a5\u53d7\u4e00\u7ebf\u6cbb\u7597\u7684\u4e0d\u53ef\u5207\u9664mCRC\u60a3\u8005\u7684<a href=\"https:\/\/gut.bmj.com\/content\/early\/2021\/09\/06\/gutjnl-2021-324852\" target=\"_blank\" rel=\"noreferrer noopener\">\u524d\u77bb\u6027\u961f\u5217<\/a>\u4e2d\u7814\u7a76\u8fd9\u4e9b\u95ee\u9898\u3002\u572874\u4f8b\uff0843.3%\uff09\u60a3\u8005\u7684ctDNA\u4e2d\u68c0\u6d4b\u5230\u57fa\u7ebfRAS\u7a81\u53d8\uff0c\u572811\u4f8b\uff086.4%\uff09\u60a3\u8005\u4e2d\u68c0\u6d4b\u51faBRAF\u7a81\u53d8\u3002\u572863\u4f8b\u60a3\u8005\u7684\u914d\u5bf9\u57fa\u7ebf\u7ec4\u7ec7\u548c\u8840\u6d46\u6837\u672c\u4e2d\uff0cctDNA\u548c\u7ec4\u7ec7\u4e4b\u95f4RAS\/BRAF<sup>V600E<\/sup>\u72b6\u6001\u7684\u603b\u4f53\u4e00\u81f4\u6027\u4e3a81%\uff0cRAS\u72b6\u6001\u7684\u4e0d\u4e00\u81f4\u7387\u4e3a17.5%\uff0cBRAF\u72b6\u6001\u7684\u4e0d\u4e00\u81f4\u7387\u4e3a1.5%\u3002\u6709\u8da3\u7684\u662f\uff0c\u4e0d\u540c\u8f6c\u79fb\u90e8\u4f4d\u4e4b\u95f4\u7684\u4e00\u81f4\u7387\u4e0d\u540c\uff08\u4ec5\u53d1\u751f\u809d\u8f6c\u79fb\u7684\u60a3\u8005\u4e3a90%\uff0c\u809d\u5916\u8f6c\u79fb\u7684\u60a3\u8005\u4e3a79.1%\uff09\u3002\u5728\u75be\u75c5\u8fdb\u5c55\uff08PD\uff09\u524d\u7684145\u4f8b\u60a3\u8005\u961f\u5217\u4e2d\u8fde\u7eed\u91c7\u96c6\u8840\u6d46\u6837\u672c\uff0c\u4ee5\u8bc4\u4f30\u4e00\u7ebf\u6cbb\u7597\u4e0b\u7684\u57fa\u56e0\u7ec4\u6f14\u53d8\u3002\u4e00\u7ebf\u6cbb\u7597\u4e00\u6bb5\u65f6\u95f4\u540e\uff08\u4e2d\u4f4d4.7\u4e2a\u6708\uff09\uff0c\u5927\u591a\u6570\u57fa\u56e0\u7684\u7a81\u53d8\u9891\u7387\u4e0b\u964d\uff0c\u5728RAS\u548cBRAF\u7a81\u53d8\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u7684\u53d8\u5316\u6700\u663e\u8457\u3002\u572842.6%\u7684RAS\u7a81\u53d8\u60a3\u8005\u4e2d\u53d1\u73b0\u4e86RAS\u7a81\u53d8\u6e05\u9664\uff0c\u572850%\u7684BRAF\u7a81\u53d8\u60a3\u8005\u4e2d\u53d1\u73b0\u4e86BRAF\u7a81\u53d8\u6e05\u9664\uff0c\u800c\u5206\u522b\u67093.6%\u548c0.7%\u7684\u60a3\u8005\u83b7\u5f97\u4e86\u65b0\u7684RAS\u548cBRAF\u7a81\u53d8\u3002<\/p>\n\n\n\n<p>\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u4e9bRAS\u548cBRAF\u7684\u57fa\u56e0\u7ec4\u53d8\u5316\u4e0e\u60a3\u8005\u7ed3\u5c40\u76f8\u5173\u3002RAS\u6216BRAF\u6e05\u9664\u60a3\u8005\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\uff08\u5206\u522b\u4e3a12.8\u4e2a\u6708\u548c\u672a\u8fbe\u5230 [NR]\uff09\u4e0eRAS\u6216BRAF\u6301\u7eed\u91ce\u751f\u578b\u60a3\u8005\u7684mPFS\u76f8\u4f3c\uff08\u5206\u522b\u4e3a13.2\u548c11.5\u4e2a\u6708\uff09\uff0c\u663e\u8457\u4f18\u4e8eRAS\u6216BRAF\u4fdd\u6301\u7a81\u53d8\u7684\u60a3\u8005\uff08\u5206\u522b\u4e3a7.9\u4e2a\u6708\u548c6.4\u4e2a\u6708\uff09\u3002\u540c\u6837\uff0cRAS\u6216BRAF\u6e05\u9664\u60a3\u8005\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08mOS\uff09\u4e0eRAS\u548cBRAF\u91ce\u751f\u578b\u60a3\u8005\u76f8\u4f3c\uff08NR vs. 31.4\u4e2a\u6708\u548c26.7\u4e2a\u6708\uff09\uff0c\u4f46RAS\u6216BRAF\u4fdd\u6301\u7a81\u53d8\u7684\u60a3\u8005mOS\u663e\u8457\u7f29\u77ed\uff0814.5\u4e2a\u6708\u548c11.4\u4e2a\u6708\uff09\u3002\u65b0\u53d1\u751fRAS\u6216BRAF\u7a81\u53d8\u7684\u60a3\u8005\u4e0eRAS\u6216BRAF\u4fdd\u6301\u7a81\u53d8\u7684\u60a3\u8005\u9884\u540e\u76f8\u4f3c\uff0cPFS\u548cOS\u77ed\u4e8e\u6301\u7eed\u91ce\u751f\u578b\u7684\u60a3\u8005\u3002\u90e8\u5206\u7f13\u89e3\u6216\u75be\u75c5\u7a33\u5b9a\u60a3\u8005\u7684ctDNA\u6c34\u5e73\u4e0b\u964d\uff0c\u75be\u75c5\u8fdb\u5c55\u60a3\u8005\u7684ctDNA\u6c34\u5e73\u5347\u9ad8\u3002\u8fd9\u8868\u660e\u4e86ctDNA\u5728\u7f13\u89e3\u8bc4\u4ef7\u4e2d\u7684\u5e94\u7528\u4ef7\u503c\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8005\u89c2\u5bdf\u5230\u4e00\u7ebf\u6cbb\u7597\u5931\u8d25\u65f6\u4f53\u7ec6\u80de\u7a81\u53d8\u7684\u663e\u8457\u53d8\u5316\u3002\u8fd9\u4e9b\u4fe1\u606f\u53ef\u80fd\u6709\u52a9\u4e8e\u5236\u5b9a\u540e\u7eed\u7684\u6cbb\u7597\u51b3\u7b56\u3002<\/p>\n\n\n\n<p>\u7814\u7a76\u7ed3\u8bba\u4e2d\uff0c\u4f5c\u8005\u5f3a\u8c03\uff0c\u8fd9\u9879\u524d\u77bb\u6027\u7814\u7a76\u4e3a\u4f7f\u7528ctDNA\u6d4b\u5e8f\u6765\u6355\u83b7mCRC\u7684\u5f02\u8d28\u6027\u548c\u80bf\u7624\u57fa\u56e0\u6f14\u53d8\u63d0\u4f9b\u4e86\u8fdb\u4e00\u6b65\u7684\u8bc1\u636e\u652f\u6301\u3002\u8fd9\u5177\u6709\u4e34\u5e8a\u610f\u4e49\uff0c\u56e0\u4e3a\u8840\u6d46RAS\u548cBRAF\u7a81\u53d8\u72b6\u6001\u7684\u53d8\u5316\u53ef\u9884\u6d4b\u60a3\u8005\u7684\u751f\u5b58\u671f\u3002<\/p>\n\n\n\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong>:<br>Wang F, et al. <em>Gut.<\/em> 2021; Sep 6 [Online ahead of print].<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u4e2d\u7684 RAS\u3001 BRAFV600E\u548cMMR\/MSI\u7b49\u5206\u5b50\u68c0\u6d4b\u662f\u5e2e\u52a9\u6539\u5584\u60a3\u8005\u7ed3\u5c40\u7684\u4e2a\u4f53\u5316\u6cbb\u7597\u9009\u62e9\u7684 [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":2652,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-2660","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u6cbb\u7597\u671f\u95f4ctDNA\u57fa\u56e0\u7ec4\u5f02\u8d28\u6027\u6216\u5f71\u54cdmCRC\u9884\u540e - ACE Oncology<\/title>\n<meta name=\"description\" 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