{"id":3116,"date":"2021-12-29T09:55:01","date_gmt":"2021-12-29T09:55:01","guid":{"rendered":"https:\/\/aceoncology.org\/?p=3116"},"modified":"2021-12-29T09:58:30","modified_gmt":"2021-12-29T09:58:30","slug":"snapshots-from-sabcs-2021","status":"publish","type":"post","link":"https:\/\/aceoncology.org\/zh-hans\/snapshots-from-sabcs-2021\/","title":{"rendered":"2021 SABCS\u4f1a\u8bae\u901f\u9012"},"content":{"rendered":"\n<p>2021\u5723\u5b89\u4e1c\u5c3c\u5965\u4e73\u817a\u764c\u5cf0\u4f1a \uff08SABCS\uff09 \u4e8e2021\u5e7412\u67087\u65e5-10\u65e5\u4e3e\u529e\uff0c\u4e73\u817a\u764c\u9886\u57df\u7814\u7a76\u8005\u3001\u4e34\u5e8a\u533b\u751f\u4ee5\u53ca\u60a3\u8005\u5021\u5bfc\u8005\u6c47\u805a\u4e00\u5802\uff0c\u5171\u540c\u4ea4\u6d41\u4e73\u817a\u764c\u9886\u57df\u6700\u65b0\u6cbb\u7597\u8fdb\u5c55\u4ee5\u53ca\u57fa\u7840\u7814\u7a76\u548c\u4e34\u5e8a\u7814\u7a76\u7684\u6700\u65b0\u6210\u679c\u3002\u672c\u6587\u5c06\u5448\u73b0\u6b64\u6b21\u5927\u4f1a\u4e2d\u53d1\u8868\u7684\u91cd\u8981\u7814\u7a76\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>\u65e9\u671fHR\u9633\u6027\u7edd\u7ecf\u524d\u4e73\u817a\u764c\u60a3\u8005<\/strong><\/li><\/ul>\n\n\n\n<p><em><a href=\"https:\/\/www.abstractsonline.com\/pp8\/#!\/10462\/presentation\/644\" target=\"_blank\" rel=\"noreferrer noopener\">\u7eb3\u51654\u9879\u968f\u673a\u7814\u7a76\u7684\u835f\u8403\u5206\u6790<\/a><\/em><br>\u8be5\u835f\u8403\u5206\u6790\u7eb3\u5165\u4e86\u5728ABCSG XII\u3001SOFT\u3001TEXT\u548cHOBOE\u968f\u673a\u7814\u7a76\u4e2d\u63a5\u53d7AI\u6216\u4ed6\u83ab\u6614\u82ac\u5185\u5206\u6ccc\u6cbb\u7597\uff08ET\uff09\u76847030\u4f8b\u6709\u5375\u5de2\u529f\u80fd\u6291\u5236\uff08OFS\uff09\u6216\u6d88\u878d\u7684\u65e9\u671fHR\u9633\u6027\u7edd\u7ecf\u524d\u5973\u6027\u4e73\u817a\u764c\u60a3\u8005\u7684\u6570\u636e\u3002ABCSG XII\u7814\u7a76\u4e2d\uff0cET\u7ed9\u836f3\u5e74\uff0c\u5728\u5176\u4ed6\u8bd5\u9a8c\u4e2d\uff0cET\u7ed9\u836f5\u5e74\u3002\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u4ed6\u83ab\u6614\u82ac\u6cbb\u7597\u76f8\u6bd4\uff0cAI\u4f7f\u590d\u53d1\u98ce\u9669\u964d\u4f4e\u4e8621%\uff08\u6bd4\u503c\u6bd4\/RR=0.98\uff0cP = 0.0005\uff09\u3002\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a8\u5e74\uff0c\u4e3b\u8981\u83b7\u76ca\u4e3a\u6cbb\u7597\u5f00\u59cb\u540e\u7684\u524d4\u5e74\uff0c\u590d\u53d1\u98ce\u9669\u964d\u4f4e32%\uff0c\u57285-9\u5e74\u95f4\u964d\u81f32%\u300210\u5e74\u65f6\uff0cAI\u7ec4\u4e73\u817a\u764c\u590d\u53d1\u7387\u4e3a14.7%\uff0c\u4ed6\u83ab\u6614\u82ac\u7ec4\u4e3a17.5%\u3002\u800cAI\u964d\u4f4e\u8fdc\u5904\u590d\u53d1\u98ce\u9669\uff08RR =0.83\uff0cP = 0.02\uff09\uff0c\u4e73\u817a\u764c\u6b7b\u4ea1\u7387\u65e0\u5dee\u5f02\u3002\u51fa\u4e4e\u610f\u6599\u7684\u662f\uff0c4\u4e2a\u53ca\u4ee5\u4e0a\u6dcb\u5df4\u7ed3\u9633\u6027\u7684\u60a3\u8005\u4f3c\u4e4e\u672a\u4eceAI\u6cbb\u7597\u4e2d\u83b7\u76ca\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u63a5\u53d7AI\u7684\u60a3\u8005\u9aa8\u6298\u53d1\u751f\u7387\u9ad8\u4e8e\u63a5\u53d7\u4ed6\u83ab\u6614\u82ac\u7684\u60a3\u8005\uff085.0% vs 3.8%\uff09\u3002<\/p>\n\n\n\n<p><em><a href=\"https:\/\/www.abstractsonline.com\/pp8\/\" target=\"_blank\" rel=\"noreferrer noopener\">SOFT + TEXT\u5408\u5e76\u5206\u6790\u7684\u66f4\u65b0<\/a><\/em><br>\u4e2d\u4f4d\u968f\u8bbf12-13\u5e74\u540e\uff0c\u4e0e\u4ed6\u83ab\u6614\u82ac + OFS\uff08T + OFS\uff09\u76f8\u6bd4\uff0c\u4f9d\u897f\u7f8e\u5766 + OFS\uff08E + OFS\uff09\u8f85\u52a9\u6cbb\u75975\u5e74\u590d\u53d1\u98ce\u9669\u7684\u6301\u7eed\u964d\u4f4e\u300212\u5e74\u65e0\u75c5\u751f\u5b58\u7387\u5206\u522b\u4e3a80.5% vs 75.9%\uff08\u98ce\u9669\u6bd4\/HR=0.79\uff09\uff1b12\u5e74\u6d78\u6da6\u6027\u4e73\u817a\u764c\u65e0\u764c\u95f4\u671f\u6539\u55844.1%\uff0c12\u5e74\u65e0\u8fdc\u5904\u590d\u53d1\u95f4\u671f\u6539\u55841.8%\u300212\u5e74\u65f6\uff0c\u4e24\u7ec4\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u5747\u8f83\u9ad8\uff0c\u63a5\u53d7E + OFS\u6cbb\u7597\u7684\u60a3\u8005\u4e3a90.1%\uff0c\u63a5\u53d7T + OFS\u6cbb\u7597\u7684\u60a3\u8005\u4e3a89.1%\u3002\u6709\u8da3\u7684\u662f\uff0c\u5bf9\u4e8e\u4e34\u5e8a\/\u75c5\u7406\u5b66\u7279\u5f81\u8f83\u5c11\u4e14\u4e0d\u9700\u8981\u5316\u7597\u7684\u60a3\u8005\uff0cSOFT\u8bd5\u9a8c\u7684\u957f\u671f\u968f\u8bbf\u7ed3\u679c\u7ee7\u7eed\u652f\u6301\u4ed6\u83ab\u6614\u82ac\u5355\u836f\u4f7f\u7528\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>\u8f6c\u79fb\u6027HR\u9633\u6027\u4e73\u817a\u764c<\/strong><\/li><\/ul>\n\n\n\n<p><em><a href=\"https:\/\/www.abstractsonline.com\/pp8\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u7b2c\u4e00\u79cd\u53e3\u670d\u96cc\u6fc0\u7d20\u53d7\u4f53\u964d\u89e3\u5242\uff08SERD\uff09 elacestrant III\u671fEMERALD\u7814\u7a76\u7684\u66f4\u65b0\u7ed3\u679c<\/a><\/em><br>\u5728EMERALD\u7814\u7a76\u4e2d\uff0c477\u4f8b\u65e2\u5f80\u63a5\u53d7\u8fc71-2\u7ebf\u5185\u5206\u6ccc\u6cbb\u7597\u548c\u22641\u7ebf\u5316\u7597\u7684\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u3001HER2\u9634\u6027\u7684\u7edd\u7ecf\u540e\u8f6c\u79fb\u6027\u4e73\u817a\u764c\uff08mBC\uff09\u60a3\u8005\u63a5\u53d7\u4e861-2\u7ebfmBC\u5185\u5206\u6ccc\u6cbb\u7597\u548c\u22641\u7ebf\u5316\u7597\uff0c\u66f4\u65b0\u4e86elacestrant\uff08\u9996\u4e2a\u53e3\u670d\u96cc\u6fc0\u7d20\u53d7\u4f53\u964d\u89e3\u5242\/SERD\uff09\u7684III\u671fEMERALD\u8bd5\u9a8c\u7ed3\u679c\uff0c\u65e2\u5f80\u5728\u5185\u5206\u6ccc\u6cbb\u7597\uff08ET\uff09\u52a0CDK 4\/6\u6291\u5236\u5242\u6cbb\u7597\u671f\u95f4\u53d1\u751f\u8fdb\u5c55\uff0c\u968f\u673a\u63a5\u53d7elacestrant\u6216\u7814\u7a76\u8005\u9009\u62e9\u7684\u6807\u51c6\u6cbb\u7597\uff08SOC\uff09ET\uff08\u6c1f\u7ef4\u53f8\u7fa4\u6216AI\uff09\u3002\u6839\u636eESR1\u7a81\u53d8\u72b6\u6001\u3001\u65e2\u5f80\u6c1f\u7ef4\u53f8\u7fa4\u66b4\u9732\u548c\u5185\u810f\u75be\u75c5\u53f2\u5bf9\u60a3\u8005\u8fdb\u884c\u5206\u5c42\u3002\u5728\u8fd9\u4e9b\u5f3a\u5316\u9884\u6cbb\u7597\u60a3\u8005\u4e2d\uff0c\u65e0\u8bba\u662f\u5426\u5b58\u5728ESR1\u7a81\u53d8\uff0celacestrant\u5747\u53ef\u6539\u5584PFS\u3002\u5728\u6240\u6709\u63a5\u53d7elacestrant\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u8fdb\u5c55\u6216\u6b7b\u4ea1\u7684\u98ce\u9669\u964d\u4f4e\u4e8630%\uff08HR=0.697\uff0cP = 0.0018\uff09\uff0c\u643a\u5e26ESR1\u7a81\u53d8\u7684\u60a3\u8005\u964d\u4f4e\u4e8645%\uff08HR=0.546\uff0cP = 0.0005\uff09\u3002\u5728\u6240\u6709\u60a3\u8005\u4e2d\uff0celacestrant\u7ec4\u768412\u4e2a\u6708PFS\u7387\u4e3a22.3%\uff0cSOC ET\u7ec4\u4e3a9.4%\uff0c\u643a\u5e26ESR1\u7a81\u53d8\u7684\u60a3\u8005\u5206\u522b\u4e3a26.8%\u548c8.2%\u3002<\/p>\n\n\n\n<p><em><a href=\"https:\/\/www.abstractsonline.com\/pp8\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6309\u7167\u5185\u5728\u4e9a\u578b\u6c47\u603b\u5206\u6790\u7684III\u671fMONALEESA-2\u3001-3\u548c-7\u7814\u7a76\u7ed3\u679c<\/a><\/em><br>\u5728MONALEESA-2\u3001-3\u548c-7\u8bd5\u9a8c\u4e2d\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u5229\u67cf\u897f\u5229+ ET\u5728HR +\/HER2-\u665a\u671f\u4e73\u817a\u764c\u60a3\u8005\u7684OS\u65b9\u9762\u8868\u73b0\u51fa\u663e\u8457\u83b7\u76ca\u3002\u5728MONALEESA-2\u3001-3\u3001-7\u8bd5\u9a8c\u7684\u6c47\u603b\u5206\u6790\u4e2d\uff0c\u5bf9\u80bf\u7624\u8fdb\u884c\u4e86PAM50\u5206\u5b50\u4e9a\u578b\u5206\u578b\uff0c\u7ed3\u679c\u663e\u793a\u5229\u67cf\u897f\u5229\u7ec4\u548c\u5b89\u6170\u5242\u7ec4\u7684\u5185\u5728\u4e73\u817a\u764c\u4e9a\u578b\u5bf9OS\u5747\u6709\u9884\u540e\u4f5c\u7528\uff08P &lt; 0.0001\uff09\uff1b\u5728\u5229\u67cf\u897f\u5229\u7ec4\u548c\u5b89\u6170\u5242\u7ec4\u4e2d\uff0c\u7ba1\u8154a\u578b\u60a3\u8005\u7684OS\u7ed3\u5c40\u5747\u6700\u4f73\uff0c\u800c\u57fa\u5e95\u6837\uff08basal-like\uff09\u4e9a\u578b\u60a3\u8005\u7684OS\u7ed3\u5c40\u6700\u5dee\u3002\u9664\u57fa\u5e95\u6837\u5916\uff0c\u5185\u5728\u4e9a\u578b\u4e5f\u53ef\u9884\u6d4bOS\uff0c\u5728\u6240\u6709\u4e9a\u578b\uff08\u7ba1\u8154a\u578b\u3001\u7ba1\u8154B\u578b\u548cHER2\u5bcc\u96c6\u578b\uff09\u4e2d\uff0c\u5229\u67cf\u897f\u5229\u6cbb\u7597\u5177\u6709\u4e00\u81f4\u7684OS\u83b7\u76ca\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u7684\u514d\u75ab\u6cbb\u7597<\/strong><\/li><\/ul>\n\n\n\n<p><em><a href=\"https:\/\/www.abstractsonline.com\/pp8\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u5173\u4e8e\u65e9\u671fTNBC\u7684KEYNOTE-522\u7814\u7a76\u7ed3\u679c\u66f4\u65b0<\/a><\/em><br>III\u671fKEYNOTE-522\u8bd5\u9a8c\u7684\u4e3b\u8981\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u5728\u65e9\u671fTNBC\u60a3\u8005\u4e2d\u6bd4\u8f83\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u65b0\u8f85\u52a9\u6cbb\u7597\u540e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8f85\u52a9\u6cbb\u7597\u76f8\u8f83\u4e8e\u5355\u7528\u65b0\u8f85\u52a9\u5316\u7597\uff0c\u65e0\u4e8b\u4ef6\u751f\u5b58\u671f\uff08EFS\uff09\u51fa\u73b0\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u6539\u5584\u3002\u4e00\u9879\u66f4\u65b0\u7684\u5206\u6790\u8868\u660e\uff0c\u57285\u9879\u9884\u5148\u89c4\u5b9a\u7684EFS\u654f\u611f\u6027\u5206\u6790\u548c\u9884\u5148\u89c4\u5b9a\u7684\u60a3\u8005\u4e9a\u7ec4\u4e2d\uff0c\u5e15\u535a\u5229\u73e0\u5355\u6297 + \u5316\u7597\u65b0\u8f85\u52a9\u6cbb\u7597\u540e\u5e15\u535a\u5229\u73e0\u5355\u6297\u8f85\u52a9\u6cbb\u7597\u7684\u6cbb\u7597\u83b7\u76ca\u7a33\u5065\u4e14\u4e00\u81f4\u3002<a href=\"https:\/\/aceoncology.org\/fda-approvals-june-and-july-2021\">FDA<\/a>\u6700\u8fd1\u6279\u51c6\u8be5\u8054\u5408\u6cbb\u7597\u7528\u4e8e\u9ad8\u5371\u3001\u65e9\u671fTNBC\u60a3\u8005\uff0c\u8fd9\u4e9b\u66f4\u65b0\u7684\u7ed3\u679c\u8fdb\u4e00\u6b65\u652f\u6301\u4e86\u8be5\u65b9\u6848\u5728\u8be5\u60a3\u8005\u4eba\u7fa4\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n\n\n\n<p><em><a href=\"https:\/\/www.abstractsonline.com\/pp8\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u5173\u4e8e\u8f6c\u79fb\u6027TNBC\u7684KEYNOTE-355\u6700\u7ec8\u7814\u7a76\u7ed3\u679c\u516c\u5e03<\/a><\/em><br>III\u671fKEYNOTE-355\u8bd5\u9a8c\u5728\u65e2\u5f80\u672a\u7ecf\u6cbb\u7597\u7684\u5c40\u90e8\u590d\u53d1\u4e0d\u53ef\u624b\u672f\u6216\u8f6c\u79fb\u6027TNBC\u60a3\u8005\u4e2d\u8bc4\u4ef7\u4e86\u5e15\u535a\u5229\u73e0\u5355\u6297\u8054\u5408\u5316\u7597\u4e0e\u5b89\u6170\u5242\u8054\u5408\u5316\u7597\u7684\u7597\u6548\u3002\u4e3b\u8981\u7ed3\u679c\u663e\u793a\uff0c\u5728\u80bf\u7624\u8868\u8fbePD-L1\u4e14CPS\u226510\u7684\u60a3\u8005\u4e2d\uff0c\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u53ef\u4f7fOS\u548cPFS\u51fa\u73b0\u7edf\u8ba1\u5b66\u663e\u8457\u6539\u5584\u3002\u6839\u636eCPS\u503c\u7684\u60a3\u8005\u4e9a\u7ec4\u7ed3\u5c40\u6700\u7ec8\u5206\u6790\u8868\u660e\uff0c\u5728CPS 1-9\u7ec4\u4e2d\uff0c\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u7597\u6548\u4e0e\u5b89\u6170\u5242\uff08\u52a0\u5316\u7597\uff09\u76f8\u5f53\uff0c\u800c\u5bf9\u4e8eCPS 10-19\u548cCPS\u226520\uff0c\u52a0\u7528\u5e15\u535a\u5229\u73e0\u5355\u6297\u7684\u6cbb\u7597\u83b7\u76ca\u76f8\u4f3c\u3002PFS\u7ed3\u679c\u4e0eOS\u57fa\u672c\u4e00\u81f4\u3002\u8be5\u7ed3\u679c\u5f3a\u8c03\u4e86CPS\u226510\u4f5c\u4e3a\u9009\u62e9\u9884\u671f\u53ef\u4ece\u5e15\u535a\u5229\u73e0\u5355\u6297\u6cbb\u7597\u4e2d\u83b7\u76ca\u7684\u8f6c\u79fb\u6027TNBC\u60a3\u8005\u7684\u5408\u7406\u4e34\u754c\u503c\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>HER2\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c<\/strong><\/li><\/ul>\n\n\n\n<p><em><a href=\"https:\/\/www.abstractsonline.com\/pp8\/#!\/10462\/presentation\/649\" target=\"_blank\" rel=\"noreferrer noopener\">DESTINY-Breast03 trial\u4e9a\u7ec4\u5206\u6790\u7ed3\u679c<\/a><\/em><br>\u5728III\u671fDESTINY-Breast03\u7814\u7a76\u4e2d\uff0c\u5728\u65e2\u5f80\u63a5\u53d7\u8fc7\u66f2\u59a5\u73e0\u5355\u6297\u548c\u7d2b\u6749\u70f7\u6cbb\u7597\u7684HER2\u9633\u6027\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u6bd4\u8f83\u4e86trastuzumab deruxtecan\uff08T-DXd\uff09\u4e0etrastuzumab 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