{"id":3817,"date":"2022-05-25T13:25:42","date_gmt":"2022-05-25T13:25:42","guid":{"rendered":"https:\/\/aceoncology.org\/?p=3817"},"modified":"2022-05-25T13:27:32","modified_gmt":"2022-05-25T13:27:32","slug":"%e8%b4%a8%e5%ad%90%e6%b3%b5%e6%8a%91%e5%88%b6%e5%89%82%e5%bd%b1%e5%93%8d%e9%98%bf%e6%9b%bf%e5%88%a9%e7%8f%a0%e5%8d%95%e6%8a%97%e6%b2%bb%e7%96%97%e6%99%9a%e6%9c%9fnsclc%e7%9a%84%e7%96%97%e6%95%88","status":"publish","type":"post","link":"https:\/\/aceoncology.org\/zh-hans\/%e8%b4%a8%e5%ad%90%e6%b3%b5%e6%8a%91%e5%88%b6%e5%89%82%e5%bd%b1%e5%93%8d%e9%98%bf%e6%9b%bf%e5%88%a9%e7%8f%a0%e5%8d%95%e6%8a%97%e6%b2%bb%e7%96%97%e6%99%9a%e6%9c%9fnsclc%e7%9a%84%e7%96%97%e6%95%88\/","title":{"rendered":"\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u5f71\u54cd\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u665a\u671fNSCLC\u7684\u7597\u6548"},"content":{"rendered":"\n

\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u7684\u4f7f\u7528\u663e\u8457\u6539\u5584\u4e86\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u751f\u5b58\u671f\uff0c\u4f46\u60a3\u8005\u7684\u751f\u5b58\u83b7\u76ca\u5177\u6709\u76f8\u5f53\u5927\u7684\u5f02\u8d28\u6027\u3002\u8bc6\u522b\u4e0eICI\u8010\u836f\u76f8\u5173\u7684\u56e0\u7d20\u662f\u4e00\u4e2a\u70ed\u70b9\u7814\u7a76\u8bfe\u9898\u3002\u4e00\u79cd\u5047\u8bbe\u662f\u5e38\u7528\u7684\u975e\u6297\u80bf\u7624\u836f\u7269\uff0c\u5982\u7834\u574f\u80a0\u9053\u83cc\u7fa4\u5e76\u5f15\u8d77\u80a0\u9053\u5fae\u751f\u6001\u5931\u8c03\u7684\u6297\u751f\u7d20\u548c\u8d28\u5b50\u6cf5\u6291\u5236\u5242\uff08PPI\uff09\uff0c\u53ef\u80fd\u5bfc\u81f4ICI\u7597\u6548\u964d\u4f4e\u3002\u7136\u800c\uff0c\u5305\u62ec\u8bc4\u4ef7\u6297\u751f\u7d20\u6216PPI\u7684\u4f7f\u7528\u4e0eICI\u7597\u6548\u4e4b\u95f4\u76f8\u5173\u6027\u7684\u968f\u673a\u5bf9\u7167\u7814\u7a76\u76843\u9879\u4e8b\u540e\u5206\u6790\u5728\u5185\u7684\u7814\u7a76\u7ed3\u679c\u5c1a\u672a\u5bf9\u6b64\u5f62\u6210\u5b9a\u8bba\u3002\u8fd1\u671f\u5bf9\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u665a\u671fNSCLC\u76845\u9879\u968f\u673a\u4e34\u5e8a\u8bd5\u9a8c\uff08IMpower 130\u3001IMpower131\u3001IMpower140\u3001OAK\u548cPOPLAR\uff09\u7684\u4e2a\u4f53\u60a3\u8005\u6570\u636e\u8fdb\u884c\u4e86\u6c47\u603b\u4e8b\u540e\u5206\u6790\uff0c\u65e8\u5728\u786e\u5b9a\u6297\u751f\u7d20\u6216PPI\u7684\u4f7f\u7528\u662f\u5426\u4f1a\u6539\u53d8ICI\u7597\u6548\u3002<\/p>\n\n\n\n

\u6c47\u603b\u961f\u5217\u5305\u62ec4458\u4f8b\u60a3\u8005\uff0c\u5176\u4e2d2723\u4f8b\u968f\u673a\u63a5\u53d7\u963f\u66ff\u5229\u73e0\u5355\u6297\u4e3a\u57fa\u7840\u7684\u6cbb\u7597\uff0c1735\u4f8b\u968f\u673a\u63a5\u53d7\u4e0d\u542b\u963f\u66ff\u5229\u73e0\u5355\u6297\u7684\u6cbb\u7597\u3002\u5728\u63a5\u53d7\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c194\u4f8b\uff087%\uff09\u5728\u5f00\u59cb\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u524d30\u5929\u5185\u63a5\u53d7\u4e86\u6297\u751f\u7d20\u6cbb\u7597\uff0c762\u4f8b\uff0828%\uff09\u5728\u5f00\u59cbICI\u5f53\u5929\u63a5\u53d7\u4e86PPI\u6cbb\u7597\u3002\u5728\u672a\u63a5\u53d7\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c91\u4f8b\uff085%\uff09\u5728\u6297\u80bf\u7624\u6cbb\u7597\u524d30\u5929\u5185\u63a5\u53d7\u4e86\u6297\u751f\u7d20\u6cbb\u7597\uff0c463\u4f8b\uff0827%\uff09\u5728\u5f00\u59cb\u6297\u80bf\u7624\u6cbb\u7597\u5f53\u5929\u63a5\u53d7\u4e86PPI\u6cbb\u7597\u3002\u5728\u6c47\u603b\u961f\u5217\u4e2d\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a19\u4e2a\u6708\u3002\u4e3b\u8981\u7ed3\u5c40\u4e3a\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u548c\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3002\u6b64\u5916\uff0c\u63a2\u7d22\u6027\u5206\u6790\u8bc4\u4ef7\u4e86\u6297\u751f\u7d20\u548cPPI\u4f7f\u7528\u4e0e\u6cbb\u7597\u524d\u5916\u5468\u8840\u514d\u75ab\u8868\u578b\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002<\/p>\n\n\n\n

\u6c47\u603b\u5206\u6790\u7684\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u672a\u670d\u7528PPI\u7684\u60a3\u8005\u76f8\u6bd4\uff0cPPI\u7684\u4f7f\u7528\u4e0e\u963f\u66ff\u5229\u73e0\u5355\u6297\u7597\u6548\u964d\u4f4e\u76f8\u5173\uff0c\u5bfc\u81f4OS\u548cPFS\u8f83\u5dee\u3002\u800c\u8fd1\u671f\u6297\u751f\u7d20\u7684\u4f7f\u7528\u5e76\u4e0d\u5f71\u54cd\u963f\u66ff\u5229\u73e0\u5355\u6297\u7684\u7597\u6548\u3002\u5728\u63a5\u53d7\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u57fa\u4e8e\u5355\u53d8\u91cf\u5206\u6790\uff08\u98ce\u9669\u6bd4[HR]= 1.30\uff0cP < 0.001\uff09\u4ee5\u53ca\u6839\u636e\u60a3\u8005\u3001\u80bf\u7624\u7279\u5f81\u548cPD-L1\u8868\u8fbe\u8fdb\u884c\u7684\u6821\u6b63\u5206\u6790\uff08HR = 1.23\uff0cP < 0.001\uff09\uff0cPPI\u7684\u4f7f\u7528\u4e0e\u8f83\u5dee\u7684OS\u76f8\u5173\u3002\u8be5\u7ed3\u679c\u5728\u4e00\u7ebf\u5316\u7597\u8054\u5408\u514d\u75ab\u548c\u540e\u7ebfICI\u5355\u836f\u6cbb\u7597\u961f\u5217\u7684\u6240\u6709\u968f\u673a\u8bd5\u9a8c\u4e2d\u4e00\u81f4\u3002\u540c\u6837\uff0c\u5728\u5355\u53d8\u91cf\uff08HR = 1.18\uff0cP < 0.001\uff09\u548c\u6821\u6b63\uff08HR = 1.15\uff0cP = 0.01\uff09\u5206\u6790\u4e2d\uff0cPPI\u7684\u4f7f\u7528\u4e0ePFS\u8f83\u5dee\u76f8\u5173\u3002\u5728\u968f\u673a\u5206\u914d\u81f3\u65e0\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u7ec4\u7684\u60a3\u8005\u4e2d\uff0c\u4f5c\u8005\u672a\u89c2\u5bdf\u5230PPI\u4f7f\u7528\u4e0eOS\uff08HR = 1.01\uff0cP = 0.87\uff09\u6216PFS\uff08HR = 0.95\uff0cP = 0.55\uff09\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002\u8bc4\u4ef7\u5916\u5468\u8840\u514d\u75ab\u8868\u578b\u7684\u63a2\u7d22\u6027\u5206\u6790\u8868\u660e\uff0c\u4f7f\u7528PPI\u4e0e\u5916\u5468\u8840\u4e2d\u6dcb\u5df4\u7ec6\u80de\u3001CD19 + \u548cCD16 + CD56 + \u514d\u75ab\u7ec6\u80de\u7684\u6cbb\u7597\u524d\u8ba1\u6570\u5206\u522b\u964d\u4f4e9%\u300118%\u548c9%\u76f8\u5173\uff08P < 0.01\uff09\u3002\u5728\u5f00\u59cb\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u524d\u63a5\u53d7\u6297\u751f\u7d20\u6cbb\u7597\u7684\u60a3\u8005\u4e2d\uff0c\u672a\u89c2\u5bdf\u5230\u514d\u75ab\u7ec6\u80de\u8ba1\u6570\u7684\u663e\u8457\u5dee\u5f02\uff0c\u4f46\u6297\u751f\u7d20\u7684\u4f7f\u7528\u4e0e\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\u5347\u9ad87%\u76f8\u5173\u3002<\/p>\n\n\n\n

\u57fa\u4e8e\u8fd9\u9879\u7814\u7a76\uff0c\u4f5c\u8005\u5f97\u51fa\u7ed3\u8bba\uff0cPPI\u7684\u4f7f\u7528\u662f\u8bc6\u522b\u963f\u66ff\u5229\u73e0\u5355\u6297\u7597\u6548\u964d\u4f4e\u7684\u4e00\u4e2a\u4e34\u5e8a\u6807\u5fd7\u7269\u3002\u7531\u4e8e\u5927\u7ea630%\u7684\u80bf\u7624\u60a3\u8005\u6b63\u5728\u670d\u7528PPI\uff0c\u56e0\u6b64\u8feb\u5207\u9700\u8981\u7814\u7a76PPI\u5982\u4f55\u5f71\u54cd\u5176\u4ed6ICI\u7684\u6d3b\u6027\uff0c\u5e76\u5236\u5b9a\u514d\u75ab\u6cbb\u7597\u7684PPI\u4f7f\u7528\u6307\u5357\u3002\u4f5c\u8005\u8fd8\u547c\u5401\u63a2\u7d22H2\u53d7\u4f53\u62ee\u6297\u5242\u548c\u6297\u9178\u836f\u5bf9\u63a5\u53d7ICI\u6cbb\u7597\u7684\u60a3\u8005\u751f\u5b58\u7ed3\u5c40\u7684\u5f71\u54cd\u3002<\/p>\n\n\n\n

\u53c2\u8003\u6587\u732e:
Hopkins AM, et al. J Thorac Oncol.<\/em> 2022 Feb 17. [Online ahead of print].<\/p>\n","protected":false},"excerpt":{"rendered":"

\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08ICI\uff09\u7684\u4f7f\u7528\u663e\u8457\u6539\u5584\u4e86\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u751f\u5b58\u671f\uff0c\u4f46\u60a3\u8005\u7684\u751f\u5b58\u83b7\u76ca\u5177\u6709\u76f8\u5f53 […]<\/p>\n","protected":false},"author":3,"featured_media":3757,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[88],"tags":[],"class_list":["post-3817","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-88"],"acf":[],"yoast_head":"\n\u8d28\u5b50\u6cf5\u6291\u5236\u5242\u5f71\u54cd\u963f\u66ff\u5229\u73e0\u5355\u6297\u6cbb\u7597\u665a\u671fNSCLC\u7684\u7597\u6548 - ACE Oncology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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