{"id":5280,"date":"2023-04-18T01:50:33","date_gmt":"2023-04-18T01:50:33","guid":{"rendered":"https:\/\/aceoncology.org\/?p=5280"},"modified":"2023-04-18T01:50:34","modified_gmt":"2023-04-18T01:50:34","slug":"2023-asco-gi%e6%b6%88%e5%8c%96%e9%81%93%e8%82%bf%e7%98%a4%e7%a0%94%e8%ae%a8%e4%bc%9a-%e4%bc%9a%e8%ae%ae%e9%80%9f%e9%80%92","status":"publish","type":"post","link":"https:\/\/aceoncology.org\/zh-hans\/2023-asco-gi%e6%b6%88%e5%8c%96%e9%81%93%e8%82%bf%e7%98%a4%e7%a0%94%e8%ae%a8%e4%bc%9a-%e4%bc%9a%e8%ae%ae%e9%80%9f%e9%80%92\/","title":{"rendered":"2023 ASCO\u00a0GI\u6d88\u5316\u9053\u80bf\u7624\u7814\u8ba8\u4f1a-\u4f1a\u8bae\u901f\u9012"},"content":{"rendered":"\n<p>ASCO\u5728\u7f8e\u56fd\u65e7\u91d1\u5c71\u4e3e\u884c\u4e86<a href=\"https:\/\/conferences.asco.org\/gi\/program\"><u>2<\/u><u>023 ASCO<\/u><u>\u6d88\u5316\u9053\u80bf\u7624\uff08GI\uff09\u7814\u8ba8\u4f1a<\/u><\/a>\u3002\u8be5\u4f1a\u8bae\u805a\u7126\u6d88\u5316\u9053\u80bf\u7624\u6cbb\u7597\u3001\u7814\u7a76\u548c\u62a4\u7406\u76f8\u5173\u7684\u591a\u5b66\u79d1\u6a21\u5f0f\u3002\u6211\u4eec\u5c06\u5206\u4eab\u5173\u4e8e\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\uff08mCRC\uff09\u3001\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u548c\u80c3\/\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\u7684\u76f8\u5173\u4f1a\u8bae\u901f\u9012\u3002<\/p>\n\n\n\n<p><strong>\u96be\u6cbb\u6027\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c<\/strong><strong><\/strong><\/p>\n\n\n\n<p>\u66f2\u6c1f\u5c3f\u82f7\u66ff\u5339\u5627\u5576\uff08FTD\/TPI\uff09\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u5728\u7ecf\u8fc7\u591a\u7ebf\u6cbb\u7597\u7684mCRC\u7684\u968f\u673aII\u671f\u7814\u7a76\u4e2d\u5c55\u73b0\u51fa\u4ee4\u4eba\u671f\u5f85\u7684\u7597\u6548\u3002\u4e4b\u540e\u8fdb\u884c\u4e86\u5168\u7403III\u671f\u7684<a href=\"https:\/\/ascopubs.org\/doi\/abs\/10.1200\/JCO.2023.41.4_suppl.4?af=R\"><u>SUNLIGHT\u7814\u7a76<\/u><\/a>\uff0c\u4ee5\u786e\u8ba4\u8be5\u7814\u7a76\u53d1\u73b0<\/p>\n\n\n\n<p>SUNLIGHT\u7814\u7a76\u5171\u7eb3\u5165\u4e86492\u4f8b\u7ecf\u8fc7\u7ec4\u7ec7\u5b66\u786e\u8bca\u7684mCRC\u60a3\u8005\uff0cECOG&nbsp;PS\u8bc4\u5206\u4e3a0\/1\uff0c\u65e2\u5f80\u63a5\u53d7\u8fc71-2\u7ebf\u665a\u671f\u5316\u7597\uff0c\u5305\u62ec\u6c1f\u5c3f\u5627\u5576\u3001\u4f0a\u7acb\u66ff\u5eb7\u3001\u5965\u6c99\u5229\u94c2\u3001\u6297VEGF\u5355\u514b\u9686\u6297\u4f53\uff08\u5982\u679c\u4ece\u533b\u5b66\u89d2\u5ea6\u8003\u91cf\u9002\u5408\uff09\u6216\u8005RAS\u91ce\u751f\u578b\u5219\u4f7f\u7528\u6297EGFR\u5355\u514b\u9686\u6297\u4f53\u3002\u60a3\u8005\u968f\u673a\u5206\u4e3a\u63a5\u53d7FTD\/TPI\u5355\u836f\uff0835mg\/m<sup>2<\/sup>\uff0c\u6bcf\u5929\u4e24\u6b21\uff0c\u7b2c1\u20135\u5929\u548c8\u201312\u5929\uff0c\u6bcf28\u5929\u4e3a\u4e00\u4e2a\u5468\u671f\uff09\u6216\u8005\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\uff085&nbsp;mg\/kg\uff0c\u7b2c1\u548c15\u5929\uff09\u3002\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a\u603b\u751f\u5b58\uff08OS\uff09\u3002<\/p>\n\n\n\n<p>\u7ed3\u679c\u663e\u793a\uff0cFTD\/TPI\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7ec4\u7684OS\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u6539\u5584\u3002FTD\/TPI\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7ec4\u7684\u4e2d\u4f4dOS\u4e3a10.8\u4e2a\u6708\uff0c\u800cFTD\/TPI\u5355\u836f\u7ec4\u4e3a7.5\u4e2a\u6708\uff08HR=0.61\uff1b95% CI\uff1a0.49-0.77\uff1bP&lt;0.001\uff09\u300212\u4e2a\u6708\u7684OS\u7387\u5206\u522b\u4e3a43%\u548c30%\u3002FTD\/TPI\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7ec4\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a5.6\u4e2a\u6708\uff0cFTD\/TPI\u5355\u836f\u7ec4\u4e3a2.4\u4e2a\u6708\uff08HR=0.44\uff1b95% CI\uff1a0.36-0.54\uff1bP&lt;0.001\uff09\u3002\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u7ec4\u22653\u7ea7\u4e0d\u826f\u4e8b\u4ef6\uff08AEs\uff09\u5e76\u6ca1\u6709\u663e\u8457\u589e\u52a0\uff0c\u7814\u7a76\u8005\u6ca1\u6709\u53d1\u73b0\u65b0\u7684\u5b89\u5168\u4fe1\u53f7\u3002<\/p>\n\n\n\n<p><a><\/a>\u6765\u81ea\u7f8e\u56fd\u5a01\u65af\u5eb7\u661f\u5927\u5b66\u9ea6\u8fea\u900a\u5206\u6821\u7684\u7279\u9080\u8ba8\u8bba\u5609\u5bbeDustin A. Deming\u6559\u6388\u6307\u51fa\uff0cFTD\/TPI\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u5e94\u88ab\u89c6\u4e3a\u96be\u6cbb\u6027mCRC\u7684\u975e\u9776\u5411\u6216\u975e\u751f\u7269\u6807\u5fd7\u7269\u9a71\u52a8\u7684\u9996\u9009\u65b9\u6848\u3002\u6b64\u5916\uff0c\u4ed6\u8fd8\u5f3a\u8c03\uff0c\u8fd9\u9879\u7814\u7a76\u5bf9\u672a\u6765\u4e09\u7ebf\u548c\u56db\u7ebf\u7684\u4e34\u5e8a\u7814\u7a76\u4e5f\u6709\u4e00\u5b9a\u63d0\u793a\u610f\u4e49\uff0c\u56e0\u4e3aFTD\/TPI\u8054\u5408\u8d1d\u4f10\u73e0\u5355\u6297\u5e94\u8be5\u88ab\u89c6\u4e3a\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n\n\n\n<p><strong>\u8f6c\u79fb\u6027\u80f0\u817a\u5bfc\u7ba1\u817a\u764c<\/strong><\/p>\n\n\n\n<p>\u8102\u8d28\u4f53\u4f0a\u7acb\u66ff\u5eb7\u8054\u5408\u6c1f\u5c3f\u5627\u5576\/\u4e9a\u53f6\u9178\u9499\uff085-FU\/LV\uff09\u5728\u7f8e\u56fd\u548c\u6b27\u6d32\u88ab\u6279\u51c6\u7528\u4e8e\u8f6c\u79fb\u6027\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08mPDAC\uff09\u60a3\u8005\uff0c\u8fd9\u4e9b\u60a3\u8005\u5728\u4ee5\u5409\u897f\u4ed6\u6ee8\u4e3a\u57fa\u7840\u7684\u6cbb\u7597\u540e\u8fdb\u5c55\u3002\u4e00\u9879\u968f\u673a\u3001\u5f00\u653e\u6807\u7b7e\u3001III\u671f<a href=\"https:\/\/meetings6.asco.org\/abstracts-presentations\/215522\"><u>NAPOLI-3\u7814\u7a76<\/u><\/a>\u6bd4\u8f83\u4e86NALIRIFOX\uff08\u4f0a\u7acb\u66ff\u5eb7\u8102\u8d28\u4f53\u6ce8\u5c04\u30015-FU\/LV\u548c\u5965\u6c99\u5229\u94c2\uff09\u4e0e\u5409\u897f\u4ed6\u6ee8\u8054\u5408\u767d\u86cb\u767d\u7d2b\u6749\u9187\uff08Gem+NabP\uff09\u4f5c\u4e3a\u4e00\u7ebf\u6cbb\u7597mPDAC\u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002<\/p>\n\n\n\n<p>\u5171\u6709770\u4f8b\u672a\u7ecf\u6cbb\u7597\u7684mPDAC\u60a3\u8005\u63a5\u53d7NALIRIFOX\u6216Gem+NabP\u6cbb\u7597\u3002\u6309ECOG PS\u8bc4\u5206\u3001\u5730\u7406\u533a\u57df\u3001\u6709\u65e0\u809d\u8f6c\u79fb\u8fdb\u884c\u968f\u673a\u5206\u5c42\u3002\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3aOS\uff0c\u6b21\u8981\u7814\u7a76\u7ec8\u70b9\u4e3aPFS\u3001\u603b\u4f53\u7f13\u89e3\u7387\u548c\u5b89\u5168\u6027\u3002<\/p>\n\n\n\n<p>\u5728\u4e2d\u4f4d\u968f\u8bbf16.1\u4e2a\u6708\u540e\uff0cNALIRIFOX\u7ec4\u7684OS\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u4e0a\u7684\u6539\u5584\uff0c\u4e2d\u4f4dOS\u4e3a11.1\u4e2a\u6708\uff0cGem+NabP\u7ec4\u4e3a9.2\u4e2a\u6708\uff08HR=0.84\uff1b95% CI\uff1a0.71-0.99\uff1bP=0.04\uff09\u3002NALIRIFOX\u961f\u5217\u4e5f\u6709\u663e\u8457\u7684PFS\u6539\u5584\uff1a7.4\u4e2a\u6708vs. 5.6\u4e2a\u6708\uff08HR=0.70\uff1b95% CI\uff1a0.59-0.84\uff1bP=0.0001)\u3002\u8fd9\u4e9bOS\u548cPFS\u5728\u5206\u5c42\u4e9a\u7ec4\u4e2d\u7684\u83b7\u76ca\u662f\u4e00\u81f4\u7684\u3002<\/p>\n\n\n\n<p>\u57fa\u4e8e\u8be5\u79ef\u6781\u7684\u7ed3\u679c\uff0c\u7814\u7a76\u8005\u8ba4\u4e3aNALIRIFOX\u65b9\u6848\u5e94\u8be5\u6210\u4e3a\u672a\u7ecf\u6cbb\u7597\u7684mPDAC\u60a3\u8005\u65b0\u7684\u6807\u51c6\u6cbb\u7597\u3002\u6765\u81ea\u7f8e\u56fd\u8303\u5fb7\u5821\u5927\u5b66\u533b\u5b66\u4e2d\u5fc3\u7684\u7279\u9080\u8ba8\u8bba\u5609\u5bbeLaura W. Goff\u6559\u6388\u6307\u51fa\uff0c\u5bf9\u4e8e\u9002\u5408\u7684\u60a3\u8005\uff0c\u8be5\u7814\u7a76\u7ed3\u679c\u652f\u6301NALIRIFOX\u65b9\u6848\u4f5c\u4e3amPDAC\u4e00\u7ebf\u6cbb\u7597\u7684\u65b0\u6807\u51c6\u3002\u7136\u800c\uff0c\u5979\u5f3a\u8c03\uff0c\u8fd9\u4e24\u79cd\u65b9\u6848\u90fd\u6709\u5f88\u9ad8\u7684\u6bd2\u6027\u53d1\u751f\u7387\u548c\u4e0d\u540c\u7684\u6bd2\u6027\u7279\u5f81\uff0c\u8fd9\u4e9b\u56e0\u7d20\u53ef\u80fd\u662f\u5728\u60a3\u8005\u6cbb\u7597\u51b3\u7b56\u8fc7\u7a0b\u4e2d\u63d0\u793a\u4e0d\u9002\u5408\u548c\u4e0d\u80fd\u8010\u53d7\u76f8\u5e94\u65b9\u6848\u3002<\/p>\n\n\n\n<p><strong>\u8f6c\u79fb\u6027\u80c3\/\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c<\/strong><strong><\/strong><\/p>\n\n\n\n<p>CLDN18.2\uff08CLDN18.2\uff09\u5728\u6b63\u5e38\u80c3\u7c98\u819c\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u4e5f\u5b58\u5728\u4e8e\u8f6c\u79fb\u6027\u80c3\/\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\uff08mG\/GEJ\uff09\u80bf\u7624\u7ec6\u80de\u3002Zolbetuximab\u662f\u4e00\u79cd\u9776\u5411CLDN18.2\u7684\u5b9e\u9a8c\u6027\u5355\u514b\u9686\u6297\u4f53\u3002\u8be5III\u671f\u5168\u7403\u53cc\u76f2<a href=\"https:\/\/meetings.asco.org\/abstracts-presentations\/217453\"><u>SPOTLIGHT\u7814\u7a76<\/u><\/a>\u6bd4\u8f83\u4e86zolbetuximab\u8054\u5408\u4e9a\u53f6\u9178\u9499\u548c5-FU\u53ca\u5965\u6c99\u5229\u94c2\uff08mFOLFOX6\uff09\u4e0e\u5b89\u6170\u5242\u8054\u5408mFOLFOX6\u4f5c\u4e3aCLDN18.2\u9633\u6027\/HER2\u9634\u6027\u5c40\u90e8\u665a\u671f\u4e0d\u53ef\u5207\u9664\u6216mG\/GEJ\u817a\u764c\u60a3\u8005\u7684\u4e00\u7ebf\u6cbb\u7597\u3002<\/p>\n\n\n\n<p>\u672a\u7ecf\u6cbb\u7597\u7684CLDN18.2\u9633\u6027\/HER2\u9634\u6027\u5c40\u90e8\u665a\u671f\u4e0d\u53ef\u5207\u9664\u6216mG\/GEJ\u817a\u764c\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\u5230zolbetuximab\uff08\u9759\u8109\u6ce8\u5c04\uff0c800mg\/m2\uff09\u8054\u5408mFOLFOX6\u7ec4\u51714\u4e2a\u5468\u671f\uff0842\u5929\u4e3a1\u4e2a\u5468\u671f\uff09\uff0c\u4e0e\u5b89\u6170\u5242\u8054\u5408mFOLFOX6\u7ec4\u76f8\u6bd4\u3002\u75be\u75c5\u6ca1\u6709\u8fdb\u5c55\u7684\u60a3\u8005\u7ee7\u7eed\u4f7f\u7528zolbetuximab\u6216\u5b89\u6170\u52424\u4e2a\u5468\u671f\uff0c\u7531\u7814\u7a76\u8005\u81ea\u884c\u51b3\u5b9a\u52a0\u7528\u4e9a\u53f6\u9178\u9499\u548c5-FU\u3002\u4e3b\u8981\u7814\u7a76\u7ec8\u70b9\u4e3a\u7531\u72ec\u7acb\u8bc4\u5ba1\u59d4\u5458\u4f1a\u6839\u636eRECIST 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