Urothelial Cancer Preceptorship
Preceptorship

Urothelial Cancer Preceptorship

The therapeutic landscape for urothelial cancer has undergone significant transformation in recent years, with the addition of PD1/PD-L1 targeting immune checkpoint inhibitors and novel targeted and antibody-drug conjugates adding to the complexity of treatment options available for patients throughout the course of their disease. The optimal sequencing of treatments depends on an understanding of the relevance of different pathological subtypes of the disease and of the latest clinical evidence and guidelines that support the use of different therapies. In this 2-day ‘Urothelial Cancer Preceptorship’, which is an in-depth interactive program of didactic lectures, case discussions, and clinical research evaluation, attendees will receive a detailed grounding of the disease process and management from diagnosis through to salvage treatments of advanced disease. The course will enable clinicians who are involved in the management of patients with urothelial cancer to integrate the latest advances and use of novel therapies for advanced urothelial cancer into safe and effective patient care.

For more information and to register for this program, please contact: info_aceoncology@aceoncology.org

Faculty

Enrique Grande, MD, MSc, PhD

Enrique Grande, MD, MSc, PhD | Chair

MD Anderson Cancer Center Madrid

Madrid, Spain

Enrique Grande is the current Director of the Medical Oncology Program at the MD Anderson Cancer Center Madrid. Dr. Grande is focused on the research into genitourinary tumors and is actively involved in collaborating on the development of the Translational Research and Early Drug Development Unit. Dr. Grande was awarded his PhD for a pharmacokinetic and pharmacodynamic study of tyrosine kinase inhibitors in liver metabolism, and he holds a master’s degree in the molecular biology of cancer from the Spanish National Cancer Research Center (CNIO). A published author of more than 200 manuscripts in peer-reviewed journals, Dr. Grande is also the founder of the Spanish group for research on orphan and uncommon tumors (GETHI). Dr. Grande is the editor of several international journals and has been the editor of a range of books related to oncology. Dr. Grande has participated in the most recent trials in the field of genitourinary and neuroendocrine tumors that led to the approval of the new drugs we now have available.

Francisco X. Real, MD, PhD

Francisco X. Real, MD, PhD

National Cancer Research Center

Madrid, Spain

Francisco X. Real (Paco) has been Professor of Cell Biology at Universitat Pompeu Fabra, Barcelona, Spain, since 2004, and he has also worked at Spanish National Cancer Research Center (CNIO), Madrid, Spain, since 2007. He obtained his MD from the Universitat Autònoma de Barcelona in 1980 and his PhD in 1986. He trained in Medical Oncology at Memorial Hospital in New York where he was a Staff Physician from 1986 to 1988. He carried out his doctoral and postdoctoral work in the laboratory of Lloyd J. Old at Memorial Sloan-Kettering Cancer Center. His work focused on the development of immunological strategies for the treatment of melanoma and epithelial cancers. In 1988, he joined the Institut Municipal d'Investigació Mèdica, Barcelona, where he focused on the cell and molecular biology of epithelial cancers. He was also involved in setting up the Biomedical Sciences studies at Universitat Pompeu Fabra.

At CNIO, Professor Real's group has made significant contributions to the molecular mechanisms involved in pancreatic cancer and in pancreatitis and the molecular pathology and epidemiology of bladder and pancreas cancer. His work combines the use of patient samples, cultured cells, and genetically modified mice, giving a similar relevance to all of them. One important aim of the group’s work is to bring the fundamental knowledge generated in the laboratory to an improved understanding of disease and to develop improved strategies for prevention, early diagnosis, and treatment of pancreatic and bladder cancer.

Professor Real has published more than 300 original papers and his work has been published in Nature, Nature Genetics, Nature Cell Biology, Nature Communications, Nature Reviews Cancer, Gut, Gastroenterology, PNAS, JNCI, J Clin Invest, N Engl J Med, and Lancet, among others. He has received more than 29,000 citations (Google Scholar); his H index is 96. He is a member of the Scientific Advisory Board of several institutions including the Discovery Research Committee of Cancer Research UK (London), Centre de Recherche des Cordeliers (Paris), CARPEM (Paris), Pancreatic Cancer Research UK (London), and Fonds National de la Recherche Scientifique (Brussels). He is an Associate Editor of Gut and Bladder Cancer. In 2015, he was President of the European Pancreatic Club.

Fernando Lista, MD, PhD

Fernando Lista, MD, PhD

MD Anderson Cancer Center Madrid

Madrid, Spain

Fernando Lista Mateos has been the Chief of the Endourology Section in the Department of Urology and Urologic Surgery at the MD Anderson Cancer Center (MDACC) Madrid, Spain, since 2014, and has notable experience in oncologic laparoscopic and robotic procedures (e.g. radical prostatectomy, nephrectomy and radical cystectomy). In addition, he is a member of the Robotic Surgery Team at MDACC Madrid, with experience in percutaneous retrograde intrarenal surgery (RIRS), HistoScanning perineal prostate biopsy, and focal therapy for prostate cancer.

Dr. Lista completed his Bachelor of Medicine at the Universidad Autonoma of Madrid in 2008 and specialized in Urology via MIR in 2014. He has since been certified as a DaVinci Console Surgeon and received a PhD in health sciences. He is a member of the Official College of Physicians of Madrid and a Fellow of the European School of Urology.

Dr. Lista is a member of several professional bodies and a board member and reviewer for several prominent scientific journals. In addition, he has been named as Investigator on several study protocols, has given many presentations at national and international conferences, and has published over 20 articles in scientific journals.

Ignacio Ortego, MD

Ignacio Ortego, MD

MD Anderson Cancer Center Madrid

Madrid, Spain

Ignacio Ortego graduated in Medicine from Universidad de Navarra, Spain, in 2015. He earned his Master’s degree in Resolution of Clinical Cases from Universidad Alcalá de Henares in 2016. During 2016 to 2021, Dr. Ortego held a Medical Oncology residency at Clínica Universidad de Navarra, and since 2021, he has been a Specialist in Medical Oncology. In addition, he was a Medical Oncologist at the Hospital HM Nou Delfos (Barcelona) between June and October 2021, and he has been the Head of Phase I Clinical Trials Unit at MD Anderson Cancer Center Madrid since October 2021. Dr. Ortega is a member of SEOM, ESMO, ASCO, and GETNE.

Juan Carlos Viera, MD

Juan Carlos Viera, MD

MD Anderson Cancer Center Madrid

Madrid, Spain

Juan Carlos Viera has been an Associate Physician of Radiation Oncology at MD Anderson Cancer Center Madrid, Spain, since 2005. He specializes in the treatment of ENT tumors, genitourinary system, and sarcomas. Previous to that, Dr. Viera was the Deputy Medical Director of Radiotherapy Oncology at the Madrid Institute of Oncology. He has also served in several institutions as an Assistant Physician: in Radiation Oncology at the Alicante Institute of Oncology, in the Emergency Service at Tafalla Health Center (Navarra), and in Radiotherapy Oncology at the Navarra University Clinic. Dr. Viera also completed his specialization (MIR) in Radiotherapy Oncology at the Navarra University Clinic.

Thursday 21 July – Day 1

 

12:00-13:30     Registration and lunch

13:30-13:45     Welcome, introductions, aims and objectives
                          Enrique Grande, MD, MSc, PhD

13:45-14:45     What an oncologist needs to know about the pathology and biology of urothelial carcinomas
                          Francisco X. Real, MD, PhD

14:45-15:05     Challenges in non-muscle-invasive urothelial carcinomas: From guidelines to new clinical trials
                          Fernando Lista, MD, PhD

15:05-15:25     Defining BCG-refractoriness in clinical practice: Case discussion
                          Fernando Lista, MD, PhD

15:25-16:00     Coffee break


16:00-16:30     Local management of muscle invasive bladder cancer: the respective roles of surgery and radiotherapy
                          Fernando Lista, MD, PhD and Juan Carlos Viera, MD

16:30-17:15     Setting the scene for systemic perioperative treatment of muscle-invasive bladder cancer: The battle between neoadjuvant
                           vs. adjuvant approaches
                          Enrique Grande, MD, MSc, PhD

17:15-18:00     Caveats to the use of immunotherapy in the adjuvant setting
                          Enrique Grande, MD, MSc, PhD

20:30               Dinner


Friday 22 July – Day 2

 

08:40-09:30     Summarizing 4 decades of systemic treatment for urothelial cancer patients in 50 minutes
                          Enrique Grande, MD, MSc, PhD

09:30-10:00     Case scenarios to classify patients as eligible vs. ineligible to cisplatin and those ineligible to any platinum-based chemo
                          All led by Enrique Grande, MD, MSc, PhD and Ignacio Ortego, MD


10:00-10:45     How can I make a difference in the treatment of urothelial cancers?
                          All delegates working in small groups


10:45-11:15     Coffee break


11:15-12:30     Guidelines vs. ‘Real Practice’? A case discussion series of different patient profiles
                          All led by Enrique Grande, MD, MSc, PhD and Ignacio Ortego, MD


12:30-13:10     New drugs and mechanisms of action under development in urothelial carcinomas
                         Enrique Grande, MD, MSc, PhD


13:10-14:00     Presentation and discussion of delegates’ research proposals
                          Enrique Grande, MD, MSc, PhD, Ignacio Ortego, MD, and Fernando Lista, MD, PhD

                          Moderator – Robert Coleman, MD, ACE Oncology


14:00-15:00     Lunch


15:00               Tour of relevant facilities and departures

This activity is design designed for medical oncologists involved or interested in the management of urothelial carcinoma.

The aim of this educational activity is for participants to:

 

  • Develop a greater awareness of the different molecular and pathologic subtypes of urothelial cancers and the role of prognostic and predictive biomarkers in patient management
  • Appreciate the current and evolving treatment options for non-muscle-invasive bladder cancer (NMIBC)
  • Become familiar with the indications and limitations of local treatments for MIBC
  • Establish confidence and expertise in the selection and timing of systemic treatment options throughout the clinical course of locally advanced and metastatic urothelial cancers
  • Develop strategies for the prevention and management of adverse events associated with the range of treatments used in the treatment of urothelial cancers
  • Improve understanding of the important research questions in urothelial cancer and how these might be addressed

This educational activity is provided by ACE Oncology.

This educational activity is supported by an independent grant from the Healthcare business of Merck KGaA, Darmstadt, Germany.

The Faculty of Pharmaceutical Medicine has approved this event for CPD and allocated it 8 continuing professional development credits (CPD).

 

This activity provides content that is evidence-based, balanced, and free of commercial bias, with a primary objective to improve the competence and performance of learners in order to improve patient care.